ArticleGenetics, selection, evolution : GSE2013
On estimation of genetic variance within families using genome-wide identity-by-descent sharing.
Article in Genetics, selection, evolution : GSE, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Correlational selection and genetic architecture shape the evolution of the leaf economics spectrum in a perennial grass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Variation in the proportion of the segregating genome shared between full-sibling cattle and sheep.Genetics, selection, evolution : GSE · 2023Article
- The genetic basis for panicle trait variation in switchgrass (Panicum virgatum).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- The genetic basis of the root economics spectrum in a perennial grass.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bias in variance component estimation in swine crossbreeding schemes using selective genotyping and phenotyping strategies.Journal of animal science · 2021Article
- Identification of genetic loci associated with higher resistance to pancreas disease (PD) in Atlantic salmon (Salmo salar L.).BMC genomics · 2020Article
- Genomic dissection of maternal, additive and non-additive genetic effects for growth and carcass traits in Nile tilapia.Genetics, selection, evolution : GSE · 2020Article
- Genomic Selection in Aquaculture: Application, Limitations and Opportunities With Special Reference to Marine Shrimp and Pearl Oysters.Frontiers in genetics · 2018Review
- Novel optimum contribution selection methods accounting for conflicting objectives in breeding programs for livestock breeds with historical migration.Genetics, selection, evolution : GSE · 2017Article
- Relatedness in the post-genomic era: is it still useful?Nature reviews. Genetics · 2015Review
- A general unified framework to assess the sampling variance of heritability estimates using pedigree or marker-based relationships.Genetics · 2015Article
- Erratum to: On estimation of genetic variance within families using genome-wide identity-by-descent sharing.Genetics, selection, evolution : GSE · 2014Article
- Alternative parameterizations of relatedness in whole genome association analysis of pre-weaning traits of Nelore-Angus calves.Genetics and molecular biology · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraditionally, heritability and other genetic parameters are estimated from between-family variation. With the advent of dense genotyping, it is now possible to compute the proportion of the genome that is shared by pairs of sibs and thus undertake the estimation within families, thereby avoiding environmental covariances of family members. Formulae for the sampling variance of estimates have been derived previously for families with two sibs, which are relevant for humans, but sampling errors are large. In livestock and plants much larger families can be obtained, and simulation has shown sampling variances are then much smaller.
methodsBased on the assumptions that realised relationship of sibs can be obtained from genomic data and that data are analyzed by restricted maximum likelihood, formulae were derived for the sampling variance of the estimates of genetic variance for arbitrary family sizes. The analysis used statistical differentiation, assuming the variance of relationships is small.
resultsThe variance of the estimate of the additive genetic variance was approximately proportional to 1/ (fn2σR2), for f families of size n and variance of relationships σR2.
conclusionsBecause the standard error of the estimate of heritability decreased in proportion to family size, the use of within-family information becomes increasingly efficient as the family size increases. There are however, limitations, such as near complete confounding of additive and dominance variances in full sib families.
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