ArticleTheoretical biology & medical modelling2013
A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model.
Article in Theoretical biology & medical modelling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multiscale modeling of drug-induced liver injury from organ to lobule.NPJ digital medicine · 2025Article
- A virtual scalable model of the Hepatic Lobule for acetaminophen hepatotoxicity prediction.NPJ digital medicine · 2024Article
- Geometrical model of lobular structure and its importance for the liver perfusion analysis.PloS one · 2021Article
- Hierarchical Modeling of the Liver Vascular System.Frontiers in physiology · 2021Article
- The liver, a functionalized vascular structure.Scientific reports · 2020Article
- Liver Bioreactor Design Issues of Fluid Flow and Zonation, Fibrosis, and Mechanics: A Computational Perspective.Journal of functional biomaterials · 2020Review
- A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions.PloS one · 2017Article
- A physiologically-based flow network model for hepatic drug elimination III: 2D/3D DLA lobule models.Theoretical biology & medical modelling · 2016Article
- Building a 3D Virtual Liver: Methods for Simulating Blood Flow and Hepatic Clearance on 3D Structures.PloS one · 2016Article
- A physiologically-based flow network model for hepatic drug elimination II: variable lattice lobule models.Theoretical biology & medical modelling · 2013Article
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Authors and funding
4 authors.
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Abstract
We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We have compared drug concentration levels observed exiting the lobule with their predicted detailed distribution inside the lobule, assuming that most often the former is accessible information while the latter is not.
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