ArticleBMC musculoskeletal disorders2013
Smoking and primary total hip or knee replacement due to osteoarthritis in 54,288 elderly men and women.
Article in BMC musculoskeletal disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Impact of smoking on the incidence and post-operative complications of total knee arthroplasty: A systematic review and meta-analysis of cohort studies.Bosnian journal of basic medical sciences · 2022Pooled it
- The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review.Journal of environmental and public health · 2018Pooled it
- No association between alcohol consumption and hip osteoarthritis: a diverse national analysis of 87,585 adults from the "All of Us" research program.Clinical rheumatology · 2026Article
- Cigarette and Electronic Cigarette Exposure in Osteoarthritis: Immune Dysregulation and Inflammatory Signaling Pathways.International journal of general medicine · 2026Article
- The effect of tobacco use on clinical outcomes in total knee arthroplasty patients.Proceedings (Baylor University. Medical Center) · 2025Article
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- Association of smoking with cartilage loss of knee osteoarthritis: data from two longitudinal cohorts.BMC musculoskeletal disorders · 2023Article
- Effect of smoking on the redox status of knee osteoarthritis: A preliminary study.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Obesity is associated with an increased risk of undergoing knee replacement in Australia.ANZ journal of surgery · 2022Article
- Developing prediction models for total knee replacement surgery in patients with osteoarthritis: Statistical analysis plan.Osteoarthritis and cartilage open · 2020Article
- Relationship Between Baseline Patient-reported Outcomes and Demographic, Psychosocial, and Clinical Characteristics: A Retrospective Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2019Article
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- The relationship between smoking and knee osteoarthritis in the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2016Article
- Association between direct and indirect smoking and osteoarthritis prevalence in Koreans: a cross-sectional study.BMJ open · 2016Article
- What is the effect of nicotinic acetylcholine receptor stimulation on osteoarthritis in a rodent animal model?SAGE open medicine · 2016Article
- Relationship between cigarette smoking and radiographic knee osteoarthritis in Chinese population: a cross-sectional study.Rheumatology international · 2015Article
- Risk factors for knee replacement due to primary osteoarthritis, a population based, prospective cohort study of 315,495 individuals.BMC musculoskeletal disorders · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe reported association of smoking with risk of undergoing a total joint replacement (TJR) due to osteoarthritis (OA) is not consistent. We evaluated the independent association between smoking and primary TJR in a large cohort.
methodsThe electronic records of 54,288 men and women, who were initially recruited for the Second Australian National Blood Pressure study, were linked to the Australian Orthopaedic Association National Joint Replacement Registry to detect total hip replacement (THR) or total knee replacement (TKR) due to osteoarthritis. Competing risk regressions that accounted for the competing risk of death estimated the subhazard ratios for TJR. One-way and probabilistic sensitivity analyses were undertaken to represent uncertainty in the classification of smoking exposure and socioeconomic disadvantage scores.
resultsAn independent inverse association was found between smoking and risk of THR and TKR observed in both men and women. Compared to non-smokers, male and female smokers were respectively 40% and 30% less likely to undergo a TJR. This significant association persisted after controlling for age, co-morbidities, body mass index (BMI), physical exercise, and socioeconomic disadvantage. The overweight and obese were significantly more likely to undergo TJR compared to those with normal weight. A dose-response relationship between BMI and TJR was observed (P < 0.001). Socioeconomic status was not independently associated with risk of either THR or TKR.
conclusionThe strengths of the inverse association between smoking and TJR, the temporal relationship of the association, together with the consistency in the findings warrant further investigation about the role of smoking in the pathogenesis of osteoarthritis causing TJR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.