ArticleMolecular biology of the cell2013
Sec16 influences transitional ER sites by regulating rather than organizing COPII.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway.Nature reviews. Molecular cell biology · 2025Review
- Characterization and functional analysis ofmBio · 2024Article
- Remodeling of the secretory pathway is coordinated withiScience · 2024Article
- ER exit in physiology and disease.Frontiers in molecular biosciences · 2024Review
- Sec16 and Sed4 interdependently function as interaction and localization partners at ER exit sites.Journal of cell science · 2023Article
- CRISPR/Cas9-mediated point mutations improve α-amylase secretion in Saccharomyces cerevisiae.FEMS yeast research · 2022Article
- Structure of the nutrient-sensing hub GATOR2.Nature · 2022Article
- TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells.Autophagy · 2021Article
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- ER arrival sites associate with ER exit sites to create bidirectional transport portals.The Journal of cell biology · 2020Article
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Sec16 function in ER export and autophagy is independent of its phosphorylation inMolecular biology of the cell · 2020Article
- Coat flexibility in the secretory pathway: a role in transport of bulky cargoes.Current opinion in cell biology · 2019Review
- Endoplasmic Reticulum Export of GPI-Anchored Proteins.International journal of molecular sciences · 2019Review
- COPII-dependent ER export in animal cells: adaptation and control for diverse cargo.Histochemistry and cell biology · 2018Review
- Signal integration in the (m)TORC1 growth pathway.Frontiers in biology · 2018Article
- Transport from the endoplasmic reticulum to the Golgi in plants: Where are we now?Seminars in cell & developmental biology · 2018Review
- Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei.Scientific reports · 2018Article
- Modulation of the secretory pathway by amino-acid starvation.The Journal of cell biology · 2018Review
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Authors and funding
8 authors.
Funding
Abstract
During the budding of coat protein complex II (COPII) vesicles from transitional endoplasmic reticulum (tER) sites, Sec16 has been proposed to play two distinct roles: negatively regulating COPII turnover and organizing COPII assembly at tER sites. We tested these ideas using the yeast Pichia pastoris. Redistribution of Sec16 to the cytosol accelerates tER dynamics, supporting a negative regulatory role for Sec16. To evaluate a possible COPII organization role, we dissected the functional regions of Sec16. The central conserved domain, which had been implicated in coordinating COPII assembly, is actually dispensable for normal tER structure. An upstream conserved region (UCR) localizes Sec16 to tER sites. The UCR binds COPII components, and removal of COPII from tER sites also removes Sec16, indicating that COPII recruits Sec16 rather than the other way around. We propose that Sec16 does not in fact organize COPII. Instead, regulation of COPII turnover can account for the influence of Sec16 on tER sites.
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