ArticleThe Journal of infectious diseases2013
Profiling of Candida albicans gene expression during intra-abdominal candidiasis identifies biologic processes involved in pathogenesis.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 63 citations in OpenAlex.
- The sulfur-related metabolic status ofVirulence · 2025Article
- Farnesol remodels the peritoneal cavity immune environment influencingInfection and immunity · 2023Article
- Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis.Intensive care medicine experimental · 2023Article
- Cdc14 phosphatase contributes to cell wall integrity and pathogenesis inFrontiers in microbiology · 2023Article
- Molecular association ofFrontiers in cellular and infection microbiology · 2023Review
- Decoding the host-pathogen interspecies molecular crosstalk during oral candidiasis in humans: anFrontiers in genetics · 2023Article
- UsingVirulence · 2022Article
- Integrative functional analysis uncovers metabolic differences between Candida species.Communications biology · 2022Article
- Therapeutic Potential of Fosmanogepix (APX001) for Intra-abdominal Candidiasis: from Lesion Penetration to Efficacy in a Mouse Model.Antimicrobial agents and chemotherapy · 2021Article
- Survival Strategies of PathogenicmBio · 2020Article
- Applying the Host-Microbe Damage Response Framework toJournal of fungi (Basel, Switzerland) · 2020Review
- Penetration of Ibrexafungerp (Formerly SCY-078) at the Site of Infection in an Intra-abdominal Candidiasis Mouse Model.Antimicrobial agents and chemotherapy · 2020Article
- Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization.mSphere · 2019Article
- Review
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- Autophagy-Inducing Factor Atg1 Is Required for Virulence in the Pathogenic FungusFrontiers in microbiology · 2019Article
- Profiling of Bacterial and Fungal Microbial Communities in Cystic Fibrosis Sputum Using RNA.mSphere · 2018Article
- Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens.ACS infectious diseases · 2018Review
- The Rim Pathway Mediates Antifungal Tolerance in Candida albicans through Newly Identified Rim101 Transcriptional Targets, Including Hsp90 and Ipt1.Antimicrobial agents and chemotherapy · 2018Article
- Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.Molecular microbiology · 2018Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe pathogenesis of intra-abdominal candidiasis is poorly understood.
methodsMice were intraperitoneally infected with Candida albicans (1 × 10(6) colony-forming units) and sterile stool. nanoString assays were used to quantitate messenger RNA for 145 C. albicans genes within the peritoneal cavity at 48 hours.
resultsWithin 6 hours after infection, mice developed peritonitis, characterized by high yeast burdens, neutrophil influx, and a pH of 7.9 within peritoneal fluid. Organ invasion by hyphae and early abscess formation were evident 6 and 24 hours after infection, respectively; abscesses resolved by day 14. nanoString assays revealed adhesion and responses to alkaline pH, osmolarity, and stress as biologic processes activated in the peritoneal cavity. Disruption of the highly-expressed gene RIM101, which encodes an alkaline-regulated transcription factor, did not impact cellular morphology but reduced both C. albicans burden during early peritonitis and C. albicans persistence within abscesses. RIM101 influenced expression of 49 genes during intra-abdominal candidiasis, including previously unidentified Rim101 targets. Overexpression of the RIM101-dependent gene SAP5, which encodes a secreted protease, restored the ability of a rim101 mutant to persist within abscesses.
conclusionsA mouse model of intra-abdominal candidiasis is valuable for studying pathogenesis and C. albicans gene expression. RIM101 contributes to persistence within intra-abdominal abscesses, at least in part through activation of SAP5.
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