ArticleJournal of virology2013
Phylogenetic patterns of human coxsackievirus B5 arise from population dynamics between two genogroups and reveal evolutionary factors of molecular adaptation and transmission.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Influence of Amino Acid Substitutions in Capsid Proteins of Coxsackievirus B5 on Free Chlorine and Thermal Inactivation.Environmental science & technology · 2024Article
- Article
- Molecular characterization of coxsackievirus B5 from the sputum of pneumonia children patients of Kunming, Southwest China.Virology journal · 2023Article
- Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred.BMC infectious diseases · 2022Article
- Article
- Article
- Observational
- Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017.Archives of virology · 2020Article
- Environmental Surveillance Can Dynamically Track Ecological Changes in Enteroviruses.Applied and environmental microbiology · 2019Article
- Molecular Characterization of Coxsackievirus B5 Isolates from Sewage, Italy 2016-2017.Food and environmental virology · 2019Article
- Molecular epidemiology of enteroviruses in Cyprus 2008-2017.PloS one · 2019Article
- Evolutionary histories of coxsackievirus B5 and swine vesicular disease virus reconstructed by phylodynamic and sequence variation analyses.Scientific reports · 2018Article
- Enterovirus genotypes among patients with severe acute respiratory illness, influenza-like illness, and asymptomatic individuals in South Africa, 2012-2014.Journal of medical virology · 2017Article
- Complete Genome Analysis of an Enterovirus EV-B83 Isolated in China.Scientific reports · 2016Article
- Viral meningitis epidemics and a single, recent, recombinant and anthroponotic origin of swine vesicular disease virus.Evolution, medicine, and public health · 2015Article
- The epidemiology of non-polio enteroviruses: recent advances and outstanding questions.Current opinion in infectious diseases · 2015Review
- Phylodynamic reconstruction of the spatiotemporal transmission and demographic history of coxsackievirus B2.BMC bioinformatics · 2015Article
- The evolution of Vp1 gene in enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99.PloS one · 2014Article
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10 authors.
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Abstract
The aim of this study was to gain insights into the tempo and mode of the evolutionary processes that sustain genetic diversity in coxsackievirus B5 (CVB5) and into the interplay with virus transmission. We estimated phylodynamic patterns with a large sample of virus strains collected in Europe by Bayesian statistical methods, reconstructed the ancestral states of genealogical nodes, and tested for selection. The genealogies estimated with the structural one-dimensional gene encoding the VP1 protein and nonstructural 3CD locus allowed the precise description of lineages over time and cocirculating virus populations within the two CVB5 clades, genogroups A and B. Strong negative selection shaped the evolution of both loci, but compelling phylogenetic data suggested that immune selection pressure resulted in the emergence of the two genogroups with opposed evolutionary pathways. The genogroups also differed in the temporal occurrence of the amino acid changes. The virus strains of genogroup A were characterized by sequential acquisition of nonsynonymous changes in residues exposed at the virus 5-fold axis. The genogroup B viruses were marked by selection of three changes in a different domain (VP1 C terminus) during its early emergence. These external changes resulted in a selective sweep, which was followed by an evolutionary stasis that is still ongoing after 50 years. The inferred population history of CVB5 showed an alternation of the prevailing genogroup during meningitis epidemics across Europe and is interpreted to be a consequence of partial cross-immunity.
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