ReviewReports on progress in physics. Physical Society (Great Britain)2013
The physics of functional magnetic resonance imaging (fMRI).
Review in Reports on progress in physics. Physical Society (Great Britain), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06797661 (Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.), which is not on this map. Cited by 130 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.
Who cites it
130 citing papers in PubMed, 2 syntheses or guidelines pooled it, 338 citations in OpenAlex.
- Drivers of resting-state fMRI heterogeneity in traumatic brain injury across injury characteristics and imaging methods: a systematic review and semiquantitative analysis.Frontiers in neurology · 2024Pooled it
- Outdoor Air Pollution and Brain Structure and Function From Across Childhood to Young Adulthood: A Methodological Review of Brain MRI Studies.Frontiers in public health · 2019Pooled it
- Pharmacological fMRI: Effects of subanesthetic ketamine on resting-state functional connectivity in the default mode network, salience network, dorsal attention network and executive control network.NeuroImage. Clinical · 2018Trial
- Reviewing Physiological Measures of Implicit Consumer Response to Food.Foods (Basel, Switzerland) · 2026Review
- Unveiling Functional-Metabolic Synergy in the Healthy Brain: Multivariate Integration of Dynamic [Human brain mapping · 2026Article
- Left frontal activity measured by fNIRS during a verbal memory task is modulated by predictability in cognitively healthy older adults.Neuroimage. Reports · 2026Article
- Brain-wide fMRI responses to auditory and visual stimuli in awake mice.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Review
- Deciphering Crossed Cerebellar Diaschisis in Patients with Large-Vessel Occlusion Acute Ischemic Stroke using BOLD Cerebrovascular Reactivity.Cerebellum (London, England) · 2026Article
- Task-induced topological and geometrical changes in whole-brain dynamics predict cognitive individual differences.bioRxiv : the preprint server for biology · 2026Article
- Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during functional magnetic resonance imaging.Nature protocols · 2026Review
- Theoretical, Technical, and Analytical Foundations of Task-Based and Resting-State Functional Magnetic Resonance Imaging (fMRI)-A Narrative Review.Biomedicines · 2026Review
- The motion sensitivity and predictive utility of different estimates of interregional functional coupling in resting-state functional MRI.Network neuroscience (Cambridge, Mass.) · 2026Article
- Assessing human scalp and brain blood flow sensitivities via superficial temporal artery occlusion using speckle contrast optical spectroscopy.APL bioengineering · 2025Article
- Resting-State Functional MRI Analyses for Brain Activity Characterization: A Narrative Review of Features and Methods.The European journal of neuroscience · 2025Review
- Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders.Brain : a journal of neurology · 2025Review
- Sketching a Space of Brain States.Neuroinformatics · 2025Article
- Review
- Minimum-Phase Property of the Hemodynamic Response Function, and Implications for Granger Causality in fMRI.Human brain mapping · 2025Article
- Human retinotopic mapping: From empirical to computational models of retinotopy.Journal of vision · 2025Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) is a methodology for detecting dynamic patterns of activity in the working human brain. Although the initial discoveries that led to fMRI are only about 20 years old, this new field has revolutionized the study of brain function. The ability to detect changes in brain activity has a biophysical basis in the magnetic properties of deoxyhemoglobin, and a physiological basis in the way blood flow increases more than oxygen metabolism when local neural activity increases. These effects translate to a subtle increase in the local magnetic resonance signal, the blood oxygenation level dependent (BOLD) effect, when neural activity increases. With current techniques, this pattern of activation can be measured with resolution approaching 1 mm(3) spatially and 1 s temporally. This review focuses on the physical basis of the BOLD effect, the imaging methods used to measure it, the possible origins of the physiological effects that produce a mismatch of blood flow and oxygen metabolism during neural activation, and the mathematical models that have been developed to understand the measured signals. An overarching theme is the growing field of quantitative fMRI, in which other MRI methods are combined with BOLD methods and analyzed within a theoretical modeling framework to derive quantitative estimates of oxygen metabolism and other physiological variables. That goal is the current challenge for fMRI: to move fMRI from a mapping tool to a quantitative probe of brain physiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.