ArticleThe Journal of experimental biology2013
Expression analysis of the speech-related genes FoxP1 and FoxP2 and their relation to singing behavior in two songbird species.
Article in The Journal of experimental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- CHIRP-Seq: FOXP2 transcriptional targets in zebra finch brain include numerous speech and language-related genes.BMC neuroscience · 2025Article
- Persistent vocal learning in an aging open-ended learner reflected in neural FoxP2 expression.BMC neuroscience · 2024Article
- Compensation between FOXP transcription factors maintains proper striatal function.Cell reports · 2024Article
- Article
- Effects of Cortical FoxP1 Knockdowns on Learned Song Preference in Female Zebra Finches.eNeuro · 2023Article
- The pale spear-nosed bat: A neuromolecular and transgenic model for vocal learning.Annals of the New York Academy of Sciences · 2022Article
- Inhibition of miR-128 Enhances Vocal Sequence Organization in Juvenile Songbirds.Frontiers in behavioral neuroscience · 2022Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- DNA Methylation Regulates Transcription Factor-Specific Neurodevelopmental but Not Sexually Dimorphic Gene Expression Dynamics in Zebra Finch Telencephalon.Frontiers in cell and developmental biology · 2021Article
- Identification ofOpen biology · 2020Article
- Birdsong as a window into language origins and evolutionary neuroscience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch.eLife · 2018Article
- FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression.Stem cell reports · 2017Article
- To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Review
- Layer-specific chromatin accessibility landscapes reveal regulatory networks in adult mouse visual cortex.eLife · 2017Article
- Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes,Frontiers in molecular neuroscience · 2017Article
- Detecting signatures of positive selection associated with musical aptitude in the human genome.Scientific reports · 2016Article
- Human mutant huntingtin disrupts vocal learning in transgenic songbirds.Nature neuroscience · 2015Article
- Differential FoxP2 and FoxP1 expression in a vocal learning nucleus of the developing budgerigar.Developmental neurobiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Humans and songbirds are among the rare animal groups that exhibit socially learned vocalizations: speech and song, respectively. These vocal-learning capacities share a reliance on audition and cortico-basal ganglia circuitry, as well as neurogenetic mechanisms. Notably, the transcription factors Forkhead box proteins 1 and 2 (FoxP1, FoxP2) exhibit similar expression patterns in the cortex and basal ganglia of humans and the zebra finch species of songbird, among other brain regions. Mutations in either gene are associated with language disorders in humans. Experimental knock-down of FoxP2 in the basal ganglia song control region Area X during song development leads to imprecise copying of tutor songs. Moreover, FoxP2 levels decrease naturally within Area X when zebra finches sing. Here, we examined neural expression patterns of FoxP1 and FoxP2 mRNA in adult Bengalese finches, a songbird species whose songs exhibit greater sequence complexity and increased reliance on audition for maintaining their quality. We found that FoxP1 and FoxP2 expression in Bengalese finches is similar to that in zebra finches, including strong mRNA signals for both factors in multiple song control nuclei and enhancement of FoxP1 in these regions relative to surrounding brain tissue. As with zebra finches, when Bengalese finches sing, FoxP2 is behaviorally downregulated within basal ganglia Area X over a similar time course, and expression negatively correlates with the amount of singing. This study confirms that in multiple songbird species, FoxP1 expression highlights song control regions, and regulation of FoxP2 is associated with motor control of song.
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