ArticleMagnetic resonance in medicine2014
Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 99 citations in OpenAlex.
- Electron-Mediated Contrast Mechanisms in Biomedical Imaging: A Narrative Review and the Implication for Emerging Techniques.Bioengineering (Basel, Switzerland) · 2026Review
- Trityl OXO71 Pharmacokinetics and Distribution in Rhesus Macaques.Magnetic resonance in medicine · 2026Article
- OxyTrack: A Novel Needle Sensor for In Situ Oximetry.Magnetic resonance in medicine · 2026Article
- Letting Biology Validate the EPR Imaging of Tumor pOAdvances in experimental medicine and biology · 2026Article
- Understanding Immune Cell Adaptation to Tumor Hypoxia for Maximized Therapeutic Efficacy of Immunotherapy: Biology and Non-invasive Imaging Application.Cancer research and treatment · 2026Review
- What Is the Information Content of EPR Oximetry?Advances in experimental medicine and biology · 2026Review
- Accurate image reconstruction from reduced data in pulsed electron paramagnetic resonance imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Compact 1 GHz electron paramagnetic resonance spectrometer and imager.The Review of scientific instruments · 2025Article
- Accelerated EPR imaging using deep learning denoising.Magnetic resonance in medicine · 2025Article
- Composite spin probes with adjustable oxygen sensitivity for pulse electron paramagnetic resonance imaging.Magnetic resonance in medicine · 2025Article
- Hypoxia studies in non‑small cell lung cancer: Pathogenesis and clinical implications (Review).Oncology reports · 2025Review
- In Vivo Mouse Abdominal Oxygen Imaging And Assessment of Subcutaneously Implanted Beta Cell Replacement Devices.Molecular imaging and biology · 2025Article
- Line-Shifting Triarylmethyl Radicals for Imaging of Enzyme Activity Using Overhauser-Enhanced Magnetic Resonance Imaging: Application to Alkaline Phosphatase.Chemical & biomedical imaging · 2025Article
- Celebration of 80 years of EPR.Applied magnetic resonance · 2024Article
- Partial Acquisition of Spectral Projections Accelerates Four-dimensional Spectral-spatial EPR Imaging for Mouse Tumor Models: A Feasibility Study.Molecular imaging and biology · 2024Article
- Oxygen Imaging of a Rabbit Tumor Using a Human-Sized Pulse Electron Paramagnetic Resonance Imager.Molecular imaging and biology · 2024Article
- Evaluations of an Early Change in Tumor Pathophysiology in Response to Radiotherapy with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE EPRI).Molecular imaging and biology · 2024Article
- Assessment of blood-brain barrier leakage and brain oxygenation in Connexin-32 knockout mice with systemic neuroinflammation using pulse electron paramagnetic resonance imaging techniques.Magnetic resonance in medicine · 2024Article
- SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance.Molecular imaging and biology · 2024Article
- Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI).Molecular imaging and biology · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTissue oxygen (O2) levels are among the most important and most quantifiable stimuli to which cells and tissues respond through inducible signaling pathways. Tumor O2 levels are major determinants of the response to cancer therapy. Developing more accurate measurements and images of tissue O2 partial pressure (pO2), assumes enormous practical, biological, and medical importance.
methodsWe present a fundamentally new technique to image pO2 in tumors and tissues with pulse electron paramagnetic resonance (EPR) imaging enabled by an injected, nontoxic, triaryl methyl (trityl) spin probe whose unpaired electron's slow relaxation rates report the tissue pO2. Heretofore, virtually all in vivo EPR O2 imaging measures pO2 with the transverse electron spin relaxation rate, R2e, which is susceptible to the self-relaxation confounding O2 sensitivity.
resultsWe found that the trityl electron longitudinal relaxation rate, R1e, is an order of magnitude less sensitive to confounding self-relaxation. R1e imaging has greater accuracy and brings EPR O2 images to an absolute pO2 image, within uncertainties.
conclusionR1e imaging more accurately determines oxygenation of cancer and normal tissue in animal models than has been available. It will enable enhanced, rapid, noninvasive O2 images for understanding oxygen biology and the relationship of oxygenation patterns to therapy outcome in living animal systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.