ArticleMagnetic resonance in medicine2014
Human cardiac 31P magnetic resonance spectroscopy at 7 Tesla.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Phosphorus Magnetic Resonance Spectroscopy (Medicina (Kaunas, Lithuania) · 2023Pooled it
- Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at 7T.Magnetic resonance in medicine · 2026Article
- Repeatability of Rapid Human Cardiac Phosphorus MRSI (Magnetic resonance in medicine · 2026Article
- Article
- Human In Vivo Cardiac Magnetic Resonance Imaging at 7 T: Feasibility, Applications, and Current Limitations-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Imaging of metabolic dysfunction in genetic cardiomyopathies.The international journal of cardiovascular imaging · 2025Review
- Regionally resolved cardiac metabolism using a dipole-loop array coil for 7 TMagnetic resonance in medicine · 2025Article
- Feasibility and comparison of 3D modified rosette ultra-short echo time (PETALUTE) with conventional weighted acquisition inScientific reports · 2025Article
- The crosstalk between mitochondrial dysfunction and fatty acid metabolism in heart failure: mechanisms and therapeutic strategies.Frontiers in pharmacology · 2025Review
- 3D ultra-short echo timeResearch square · 2024Article
- Mapping intracellular NAD content in entire human brain using phosphorus-31 MR spectroscopic imaging at 7 Tesla.Frontiers in neuroscience · 2024Article
- Dual-frequency resonant coil design for low-γ X-nuclear and proton magnetic resonance imaging at ultrahigh fields.NMR in biomedicine · 2023Article
- PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans.Scientific reports · 2023Article
- Compartment-based reconstruction of 3D acquisition-weightedNMR in biomedicine · 2023Article
- Three-dimensional, 2.5-minute, 7T phosphorus magnetic resonance spectroscopic imaging of the human heart using concentric rings.NMR in biomedicine · 2023Article
- Compartment-based reconstruction of acquisition-weightedFrontiers in physiology · 2023Article
- Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research.Frontiers in cardiovascular medicine · 2023Article
- Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease.Neuroimage. Reports · 2022Article
- Magnetic resonance imaging of cardiac metabolism in heart failure: how far have we come?European heart journal. Cardiovascular Imaging · 2022Article
- In Vivo Magnetic Resonance Spectroscopy Methods for Investigating Cardiac Metabolism.Metabolites · 2022Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposePhosphorus magnetic resonance spectroscopy ((31)P-MRS) affords unique insight into cardiac energetics but has a low intrinsic signal-to-noise ratio (SNR) in humans. Theory predicts an increased (31)P-MRS SNR at 7T, offering exciting possibilities to better investigate cardiac metabolism. We therefore compare the performance of human cardiac (31)P-MRS at 7T to 3T, and measure T1s for (31)P metabolites at 7T.
methodsMatched (31)P-MRS data were acquired at 3T and 7T, on nine normal volunteers. A novel Look-Locker CSI acquisition and fitting approach was used to measure T1s on six normal volunteers.
resultsT1s in the heart at 7T were: phosphocreatine (PCr) 3.05 ± 0.41s, γ-ATP 1.82 ± 0.09s, α-ATP 1.39 ± 0.09s, β-ATP 1.02 ± 0.17s and 2,3-DPG (2,3-diphosphoglycerate) 3.05 ± 0.41s (N = 6). In the field comparison (N = 9), PCr SNR increased 2.8× at 7T relative to 3T, the Cramer-Ráo uncertainty (CRLB) in PCr concentration decreased 2.4×, the mean CRLB in PCr/ATP decreased 2.7× and the PCr/ATP SD decreased 2×.
conclusionCardiac (31)P-MRS at 7T has higher SNR and the spectra can be quantified more precisely than at 3T. Cardiac (31)P T1s are shorter at 7T than at 3T. We predict that 7T will become the field strength of choice for cardiac (31)P-MRS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.