ArticleInternational journal of geriatric psychiatry2014
Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old age.
Article in International journal of geriatric psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Confining the Concept of Vascular Depression to Late-Onset Depression: A Meta-Analysis of MRI-Defined Hyperintensity Burden in Major Depressive Disorder and Bipolar Disorder.Frontiers in psychology · 2019Pooled it
- Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review.Current psychiatry reports · 2015Pooled it
- Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites.Bipolar disorders · 2026Article
- Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review.Journal of psychiatry and brain science · 2022Article
- White Matter Microstructural Changes and Episodic Memory Disturbances in Late-Onset Bipolar Disorder.Frontiers in psychiatry · 2018Article
- Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study.Canadian geriatrics journal : CGJ · 2015Article
- Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder.Bipolar disorders · 2015Article
- The relationship between interleukin-1 receptor antagonist and cognitive function in older adults with bipolar disorder.International journal of geriatric psychiatry · 2014Article
- Aging changes and medical complexity in late-life bipolar disorder: emerging research findings that may help advance care.Neuropsychiatry · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesCognitive dysfunction is prevalent in older adults with bipolar disorder (BD). High white matter hyperintensity (WMH) burden, a marker of white matter disease, detected on T2/fluid-attenuated inversion recovery brain magnetic resonance imaging (MRI) has been consistently reported in BD across all age ranges, including older adults. Yet, whether high WMH burden is related to the excess cognitive impairment present in older adults with BD is unknown. Therefore, we examine whether higher WMH burden is related to worse cognitive function in older adults with BD.
methodsThis is a cross-sectional study of 27 non-demented BD patients aged ≥50 years and 12 similarly aged mentally healthy comparators (controls). Subjects underwent both brain MRI and comprehensive neurocognitive assessment. We employed correlational analyses to evaluate the burden of WMH and the relationship between WMH and cognitive function.
resultsAlthough BD subjects had worse performance in all cognitive domains, BD subjects had less total WMH burden (t[13.4] = -3.57, p = 0.003). In control subjects, higher WMH was related to lower global cognitive function (ρ = -0.57, n = 12, p = 0.05). However, WMH did not correlate with neuropsychological performance in BD subjects. Further, BD and control subjects did not differ with respect to total gray and hippocampal volumes.
conclusionsCognitive dysfunction in late-life BD does not appear to be due primarily to processes related to increased WMH or reduced gray matter volume. Future longitudinal studies should examine other potential neuroprogressive pathways such as inflammation, mitochondrial dysfunction, serum anticholinergic burden, and altered neurogenesis.
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