ArticleMagnetic resonance in medicine2013
Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin.
Article in Magnetic resonance in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarizedMagnetic resonance in medicine · 2024Article
- Preclinical MRI Using HyperpolarizedMolecules (Basel, Switzerland) · 2022Review
- HyperpolarizedRadiology · 2021Article
- Improved preclinical hyperpolarizedNMR in biomedicine · 2021Article
- Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI.Magnetic resonance in medicine · 2020Article
- Preclinical hyperpolarizedNMR in biomedicine · 2020Article
- Quantification of Ventilation and Gas Uptake in Free-Breathing Mice With HyperpolarizedIEEE transactions on medical imaging · 2019Article
- A portable ventilator with integrated physiologic monitoring for hyperpolarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging.Scientific reports · 2018Article
- Establishing an accurate gas phase reference frequency to quantifyMagnetic resonance in medicine · 2017Article
- HyperpolarizedJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2017Article
- Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.Magnetic resonance in medicine · 2016Article
- 3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis.NMR in biomedicine · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeHyperpolarized (HP) (129) Xe gas in the alveoli can be detected separately from (129) Xe dissolved in pulmonary barrier tissues (blood plasma and parenchyma) and red blood cells (RBCs) of humans, allowing this isotope to probe impaired gas uptake. Unfortunately, mice, which are favored as lung disease models, do not display a unique RBC resonance, thus limiting the preclinical utility of (129) Xe MR. Here we overcome this limitation using a commercially available strain of transgenic mice that exclusively expresses human hemoglobin.
methodsDynamic HP (129) Xe MR spectroscopy, and three-dimensional radial MRI of gaseous and dissolved (129) Xe were performed in both wild-type (C57BL/6) and transgenic mice.
resultsUnlike wild-type animals, transgenic mice displayed two dissolved (129) Xe NMR peaks at 198 and 217 ppm, corresponding to (129) Xe dissolved in barrier tissues and RBCs, respectively. Moreover, signal from these resonances could be imaged separately, using a 1-point variant of the Dixon technique.
conclusionIt is now possible to examine the dynamics and spatial distribution of pulmonary gas uptake by the RBCs of mice using HP (129) Xe MR spectroscopy and imaging. When combined with ventilation imaging, this ability will enable translational "mouse-to-human" studies of impaired gas exchange in a variety of pulmonary diseases.
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