ArticleEuropean journal of nuclear medicine and molecular imaging2014
Test-retest reliability of [11C]AZ10419369 binding to 5-HT(1B) receptors in human brain.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- A randomized placebo-controlled PET study of ketamine´s effect on serotoninTranslational psychiatry · 2020Trial
- Convergent increases in serotonin 1B receptor binding following ketamine and electroconvulsive therapy: a multi-centre bayesian re-analysis of PET data.Molecular psychiatry · 2026Article
- The serotonin transporter and the serotonin 1B receptor in relation to social cognition in healthy adults.EJNMMI research · 2026Article
- A reference tissue implementation of Simultaneous Multifactor Bayesian Analysis (SiMBA) of PET time activity curve data.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Altered Serotonin 1B Receptor Binding After Escitalopram for Depression Is Correlated With Treatment Effect.The international journal of neuropsychopharmacology · 2024Article
- Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [11C]AZ10419369 Positron Emission Tomography Study.The international journal of neuropsychopharmacology · 2023Article
- First-in-Humans Brain PET Imaging of the GluN2B-ContainingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Radiotracers for the Central Serotoninergic System.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Early stopping in clinical PET studies: How to reduce expense and exposure.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Review
- Kinfitr - an open-source tool for reproducible PET modelling: validation and evaluation of test-retest reliability.EJNMMI research · 2020Article
- Quantification and reliability of [EJNMMI research · 2020Article
- Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding.JAMA neurology · 2019Article
- Article
- [EJNMMI research · 2018Article
- Serotonin concentration enhancers at clinically relevant doses reduce [Translational psychiatry · 2018Article
- Test-retest reproducibility of [EJNMMI research · 2017Article
- OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding.Journal of affective disorders · 2016Article
- Application of cross-species PET imaging to assess neurotransmitter release in brain.Psychopharmacology · 2015Review
- Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943.European journal of nuclear medicine and molecular imaging · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose[(11)C]AZ10419369 is a recently developed 5-HT1B receptor radioligand that is sensitive to changes in endogenous serotonin concentrations in the primate brain. Thus, [(11)C] AZ10419369 may serve as a useful tool in clinical studies of the pathophysiology and pharmacological treatment of diseases related to the serotonin system, such as depression and anxiety disorders. The aim of this study was to evaluate the test-retest reliability of [(11)C]AZ10419369.
methodsEight men were examined with PET and [(11)C] AZ10419369 twice on the same day. The binding potentials (BPND) of [(11)C]AZ10419369 in selected serotonergic projection areas and in the raphe nuclei (RN) were determined using the simplified reference tissue model, and for comparison also using a wavelet-aided parametric imaging approach. The BPND values obtained from the first and second PET scans were compared by means of descriptive statistics, difference, absolute variability and intraclass correlation coefficient.
resultsSimilar BPND values were obtained with the two methods. The absolute mean differences in BPND between PET 1 and PET 2 were less than 3% in all serotonergic projection regions. Absolute variabilities were low in cortical regions (5 - 7%), low to moderate (7 - 14%) in subcortical regions, but higher (20%) in the RN.
conclusionThe BPND of [(11)C]AZ10419369 is highly reproducible in cortical regions and satisfactory in subcortical projection areas. The variability in the RN is higher. Thus larger sample sizes or larger divergences are required to assess a potential difference between subjects or between experimental conditions in this region.
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