Evidence map›Paper›PMID 24006131›Full record

ReviewAnnals of biomedical engineering2014

Mechanochemitry: a molecular biomechanics view of mechanosensing.

Cheng Zhu

Abstract readReview
In one paragraph

Review in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Cheng ZhuCoulter Department of Biomedical Engineering, Woodruff School of Mechanical Engineering, and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA, cheng.zhu@bme.gatech.edu.

Funding

Visualizing Single Integrin Conformational Changes on Living CellsR01AI044902 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2000 to 2016
$5.8M
Mechanical Regulation of Selectin-Ligand Binding KineticsR01AI077343 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI MCEVER, RODGER PAUL, ZHU, CHENG · 2010 to 2014
$2.5M
Ligand Binding Kinetics and Cell Adhesion by Fc ReceptorR01AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2001 to 2005
$1.9M
Biophysical Analysis of GPIb-VWF InteractionR01HL091020 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2008 to 2012
$1.8M
Mechanical Regulation of Binding and Cleavage of VWF by ADAMTS-13R01HL093723 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2009 to 2012
$1.5M
Statistical Modeling of Receptor/Ligand Binding Kinetics on the T cell SurfaceR01GM096187 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI WU, CHIEN-FU JEFF · 2010 to 2012
$879k
Kinetic analysis of ligand binding by TCR and CD8R56AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2012 to 2012
$389k
Structural bases of ADAMTS-13 and VWF A2 interactionsR03TW008753 · FIC · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2011 to 2013
$176k
Mechanical regulation of selectin-ligand binding kineticsR56AI077343 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2008 to 2008
$151k
KINETIC PROPERTIES OF SELECTINSR21AI044902 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2000 to 2000
$71k
LIGAND BONDING FORCE AND CELL ADHESION BY CD16 ISOFORMSR29AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 1995 to 1999
–
FIC NIH HHS R03 TW008753FIC NIH HHS TW008753NHLBI NIH HHS HL091020NHLBI NIH HHS HL093723NHLBI NIH HHS R01 HL091020NHLBI NIH HHS R01 HL093723NIAID NIH HHS AI038282NIAID NIH HHS AI077343NIAID NIH HHS AI44902NIAID NIH HHS R01 AI038282NIAID NIH HHS R01 AI044902NIAID NIH HHS R01 AI077343NIAID NIH HHS R21 AI044902NIAID NIH HHS R29 AI038282NIAID NIH HHS R56 AI038282NIAID NIH HHS R56 AI077343NIGMS NIH HHS GM096187NIGMS NIH HHS R01 GM096187
6 · The paper itself

Abstract

Molecular biomechanics includes two themes: the study of mechanical aspects of biomolecules and the study of molecular biology of the cell using mechanical tools. The two themes are interconnected for obvious reasons. The present review focuses on one of the interconnected areas-the mechanical regulation of molecular interaction and conformational change. Recent conceptual developments are summarized, including catch bonds, regulation of molecular interaction by the history of force application, and cyclic mechanical reinforcement. These studies elucidate the mechanochemistry of some of the candidate mechanosensing molecules, thereby providing a natural connection to mechanobiology.

Indexed as

Mechanotransduction, CellularModels, BiologicalAnimalsBiomechanical PhenomenaHumans

Identifiers

PMID24006131
PMCPMC3943982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.