ArticleVirus genes2013
Hepatitis B virus subgenotype A1, occurrence of subgenotype D4, and S gene mutations among voluntary blood donors in Kenya.
Article in Virus genes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Seroprevalence of human immunodeficiency virus in African blood donors: a systematic review and meta-analysis.EBioMedicine · 2024Pooled it
- Molecular characterization of hepatitis B virus genotypes A and D among inmates and blood donors in Northeastern Kenya.PloS one · 2026Article
- A systematic review of Hepatitis B virus (HBV) prevalence and genotypes in Kenya: Data to inform clinical care and health policy.PLOS global public health · 2023Article
- Genetic diversity, haplotype analysis, and prevalence of Hepatitis B virus MHR mutations among isolates from Kenyan blood donors.PloS one · 2023Article
- Disproportionate Distribution of HBV Genotypes A and D and the Recombinant Genotype D/E in the High and Low HBV Endemic Regions of Uganda: A Wake-Up Call for Regional Specific HBV Management.International journal of hepatology · 2022Article
- Seroprevalence and genotypic characterization of HBV among low risk voluntary blood donors in Nairobi, Kenya.Virology journal · 2020Article
- Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas.PloS one · 2019Article
- Genotyping and sero-virological characterization of hepatitis B virus (HBV) in blood donors, Southern Ethiopia.PloS one · 2018Article
- Hepatitis B infection is highly prevalent among patients presenting with jaundice in Kenya.BMC infectious diseases · 2016Article
- Hepatitis B virus genotypes A and D in Uganda.Journal of virus eradication · 2016Article
- Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and Non-injection drug users from coastal Kenya.BMC infectious diseases · 2015Article
- Hepatitis B virus infection in post-vaccination South Africa: occult HBV infection and circulating surface gene variants.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
- Hepatitis B virus subgenotype A1: evolutionary relationships between Brazilian, African and Asian isolates.PloS one · 2014Article
- A rare HBV subgenotype D4 with unique genomic signatures identified in north-eastern India--an emerging clinical challenge?PloS one · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kenya is one of the high endemic zones for hepatitis B virus (HBV) infection. The consensuses on prevalence of the HBV genotypes and the existence of their variants have not been fully established in Kenya. Hence, there is a need to further monitor the diversity of HBV. This study aimed to extend the current molecular and epidemiological information about the geographical distribution of HBV genotypes and subgenotypes, as well as to describe the hepatitis B surface antigen (HBsAg) variants circulating in different Regional Blood Transfusion Centres of Kenya. A total of 32 HBsAg positive blood units from five different blood transfusion centers in Kenya were used in the study. The HBV DNA preS/S-gene was amplified and sequenced. Alignments of S gene were applied using reference sequence from GeneBank. Phylogenetic analysis was performed using the MEGAv4.0 software with the neighbor-joining and maximum composite likelihood methods. Twenty-one plasma samples (65.6%) were DNA positive and were successfully sequenced. Eighteen out of the twenty-one isolates (85.7%) belonged to subgenotype A1 Afro-Asian: six were from Nairobi, four from Kisumu, two from Embu, and three each from Eldoret and Mombasa. The other three strains (14.3%, 3/21) belonged to subgenotype D4 from Mombasa. The HBsAg mutations were detected in nine isolates (42.9%, 9/21). The HBV/A1 and HBV/D4 are dominant among blood donors in Kenya. This demonstrates that continuous monitoring of the HBV diversity would help reveal circulating genotypes and subgenotypes as well as mutants of clinical significance in Kenya.
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