ReviewJournal of cardiovascular translational research2013
Role of inflammation and its mediators in acute ischemic stroke.
Review in Journal of cardiovascular translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
230 citing papers in PubMed, 11 syntheses or guidelines pooled it, 418 citations in OpenAlex.
- Endovascular thrombectomy plus intravenous thrombolysis versus endovascular thrombectomy alone for large ischemic stroke.Acta neurologica Belgica · 2026Pooled it
- From Mechanism to Therapy: Isoliquiritigenin as a Novel Anti-Inflammatory Agent for Inflammatory Disease ManagementEndocrine, metabolic & immune disorders drug targets · 2026Pooled it
- Prediction Models for Acute Kidney Injury in Stroke Patients: A Systematic Review.Brain and behavior · 2026Pooled it
- The Neuroprotective Mechanisms of Kaempferol in Experimental Ischemic Stroke: A Preclinical Systematic Review.Molecular neurobiology · 2025Pooled it
- Meta-analysis of the efficacy of external application of Chinese medicine in the treatment of lower limb motor impairment in patients with post-stroke hemiplegia.Frontiers in neurology · 2025Pooled it
- Global research trends and prospects on immune-related therapy in ischemic stroke: a bibliometric analysis.Frontiers in cellular neuroscience · 2024Pooled it
- Endovascular thrombectomy without versus with different pre-intravenous thrombolysis in acute ischemic stroke: a network meta-analysis of randomized controlled trials.Frontiers in neurology · 2024Pooled it
- Herpesvirus latent infection promotes stroke via activating the OTUD1/NF-κB signaling pathway.Aging · 2023Pooled it
- Prognostic value of the neutrophil-to-lymphocyte ratio in acute ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis.BMC neurology · 2021Pooled it
- Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemic stroke: A meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Clinical Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Patients With Ischemic Stroke or Hemorrhagic Stroke: An Updated Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial.Oxidative medicine and cellular longevity · 2022Trial
- Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids: a randomized, double-blind, placebo-controlled, pilot trial.Inflammopharmacology · 2019Trial
- Acupuncture for Poststroke Dysphagia: An NTS-Centered Hypothesis-Generating Framework Linking the Brainstem Swallowing Network, Neuroimmune Regulation, and Vagal Anti-Inflammatory Signaling.Brain and behavior · 2026Review
- Dysfunction of hippocampal cells and its role in cognitive impairment.Neural regeneration research · 2026Article
- Untargeted Metabolomic Signature of Mice with Ischemic Stroke.Metabolites · 2026Article
- Association of high-sensitivity C-reactive protein-triglyceride glucose index and stroke outcomes: results from the China National Stroke Registry III.BMC neurology · 2026Article
- Nanomedicines and stroke: Advantages in chronic inflammation treatment and neural regeneration.Neural regeneration research · 2026Article
- Target trial emulation of early acetaminophen use and mortality in critically ill stroke patients.Scientific reports · 2026Article
- The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives.MedComm · 2026Review
170 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms of ischemic brain injury. Increasing evidence suggests that inflammatory response is a double-edged sword, as it not only exacerbates secondary brain injury in the acute stage of stroke but also beneficially contributes to brain recovery after stroke. In this article, we provide an overview on the role of inflammation and its mediators in acute ischemic stroke. We discuss various pro-inflammatory and anti-inflammatory responses in different phases after ischemic stroke and the possible reasons for their failures in clinical trials. Undoubtedly, there is still much to be done in order to translate promising pre-clinical findings into clinical practice. A better understanding of the dynamic balance between pro- and anti-inflammatory responses and identifying the discrepancies between pre-clinical studies and clinical trials may serve as a basis for designing effective therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.