ArticlePsychopharmacology2014
Effects of dopamine receptor antagonists on the acquisition of ethanol-induced conditioned place preference in mice.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Nonlinear dose-dependent impact of D1 receptor activation on motor cortex plasticity in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Dopamine D2 and GABA(A) Receptors Differentially Regulate Ethanol-Induced Aversion and Reward Through Corticolimbic Circuits.International journal of molecular sciences · 2026Article
- Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward.Biology of sex differences · 2025Article
- Changes in responses of the amygdala and hippocampus during fear conditioning are associated with persecutory beliefs.Scientific reports · 2024Article
- Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice.Neurobiology of stress · 2024Article
- Genetic disruption of dopamine β-hydroxylase dysregulates innate responses to predator odor in mice.bioRxiv : the preprint server for biology · 2024Article
- Neural processing of the reward value of pleasant odorants.Current biology : CB · 2021Article
- 4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels.Psychopharmacology · 2020Article
- Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals.Frontiers in neuroscience · 2019Article
- Dissociable roles of the nucleus accumbens D1 and D2 receptors in regulating cue-elicited approach-avoidance conflict decision-making.Psychopharmacology · 2018Article
- Effect of Yulangsan Polysaccharide on the Reinstatement of Morphine-Induced Conditioned Place Preference in Sprague-Dawley Rats.Neurochemical research · 2018Article
- Ayahuasca and Its DMT- and β-carbolines - Containing Ingredients Block the Expression of Ethanol-Induced Conditioned Place Preference in Mice: Role of the Treatment Environment.Frontiers in pharmacology · 2018Article
- Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice.Psychopharmacology · 2017Article
- Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters.Frontiers in behavioral neuroscience · 2015Article
- Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior.Neurobiology of learning and memory · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleStudies support differential roles of dopamine receptor subfamilies in the rewarding and reinforcing properties of drugs of abuse, including ethanol. However, the roles these receptor subfamilies play in ethanol reward are not fully delineated.
objectiveTo examine the roles of dopamine receptor subfamilies in the acquisition of ethanol-induced conditioned place preference (CPP), we pretreated animals systemically with antagonist drugs selective for dopamine D1-like (SCH-23390) and D2-like (raclopride) receptors prior to ethanol conditioning trials.
methodsEffects of raclopride (0-1.2 mg/kg) and SCH-23390 (0-0.3 mg/kg) on the acquisition of ethanol-induced CPP were examined in DBA/2J mice (experiments 1 and 2). Based on significant effects of SCH-23390, we then determined if SCH-23390 (0.3 mg/kg) produced a place preference on its own (experiment 3). To evaluate whether SCH-23390 impaired learning, we used a conditioned place aversion (CPA) paradigm and pretreated animals with SCH-23390 (0-0.3 mg/kg) before conditioning sessions with LiCl (experiment 4).
resultsWhereas raclopride (0-1.2 mg/kg) did not affect acquisition, SCH-23390 (0.1-0.3 mg/kg) impaired the development of ethanol-induced CPP. SCH-23390 (0.3 mg/kg) did not produce place preference when tested alone and SCH-23390 (0.1-0.3 mg/kg) did not perturb the acquisition of LiCl-induced CPA.
conclusionsOur results support a role for dopamine D1-like but not D2-like receptors in ethanol's unconditioned rewarding effect as indexed by CPP. Blockade of D1-like receptors did not affect aversive learning in this procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.