ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Stochastic properties of neurotransmitter release expand the dynamic range of synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Computational insights on drug effects on intrinsic stochasticity of mouse pacemaker cell activity.Biophysical journal · 2025Article
- Investigation of Signal Transmission Dynamics in Rulkov Neuronal Networks with Q-Learned Pathways.Entropy (Basel, Switzerland) · 2025Article
- Synapses learn to utilize stochastic pre-synaptic release for the prediction of postsynaptic dynamics.PLoS computational biology · 2024Article
- Homeostatic synaptic plasticity rescues neural coding reliability.Nature communications · 2023Article
- Opening the Schrödinger Box: Short- and Long-Range Mammalian Heart Rate Variability.Frontiers in physiology · 2021Article
- Mechanisms and Functional Consequences of Presynaptic Homeostatic Plasticity at Auditory Nerve Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Synaptic mechanisms for motor variability in a feedforward network.Science advances · 2020Article
- Beating Rate Variability of Isolated Mammal Sinoatrial Node Tissue: Insight Into Its Contribution to Heart Rate Variability.Frontiers in neuroscience · 2020Article
- A cortical model with multi-layers to study visual attentional modulation of neurons at the synaptic level.Cognitive neurodynamics · 2019Article
- Skipped-stimulus approach reveals that short-term plasticity dominates synaptic strength during ongoing activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Motor neuronal activity varies least among individuals when it matters most for behavior.Journal of neurophysiology · 2015Article
- NMDA Receptors Mediate Stimulus-Timing-Dependent Plasticity and Neural Synchrony in the Dorsal Cochlear Nucleus.Frontiers in neural circuits · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Release of neurotransmitter is an inherently random process, which could degrade the reliability of postsynaptic spiking, even at relatively large synapses. This is particularly important at auditory synapses, where the rate and precise timing of spikes carry information about sounds. However, the functional consequences of the stochastic properties of release are unknown. We addressed this issue at the mouse endbulb of Held synapse, which is formed by auditory nerve fibers onto bushy cells (BCs) in the anteroventral cochlear nucleus. We used voltage clamp to characterize synaptic variability. Dynamic clamp was used to compare BC spiking with stochastic or deterministic synaptic input. The stochastic component increased the responsiveness of the BC to conductances that were on average subthreshold, thereby increasing the dynamic range of the synapse. This had the benefit that BCs relayed auditory nerve activity even when synapses showed significant depression during rapid activity. However, the precision of spike timing decreased with stochastic conductances, suggesting a trade-off between encoding information in spike timing versus probability. These effects were confirmed in fiber stimulation experiments, indicating that they are physiologically relevant, and that synaptic randomness, dynamic range, and jitter are causally related.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.