ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Chronic stress-induced alterations of dendritic spine subtypes predict functional decrements in an hypothalamo-pituitary-adrenal-inhibitory prefrontal circuit.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Successful pharmacotherapy for the treatment of severe feeding aversion with mechanistic insights from cross-species neuronal remodeling.Translational psychiatry · 2017Trial
- NeuronaleNeuro · 2026Article
- Unique mushroom spine morphology signature in cocaine relapse ensembles in rat nucleus accumbens core.bioRxiv : the preprint server for biology · 2026Article
- Antidepressant-like effects of extinction learning as an animal model of behavioral therapy.Molecular psychiatry · 2026Article
- Prefrontal spine loss in neuropsychiatric disorders: circuit consequences for cognition.Frontiers in psychiatry · 2026Review
- Action inflexibility and compulsive-like behavior accompany neurobiological alterations in the anterior orbitofrontal cortex and associated striatal nuclei.Scientific reports · 2025Article
- Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories.Research square · 2024Article
- Social experience in adolescence shapes prefrontal cortex structure and function in adulthood.Molecular psychiatry · 2024Article
- Article
- Repeated exposure to multiple concurrent stressors alters visual processing in the adult posterior parietal cortex.Neurobiology of stress · 2024Article
- Morphology and Fractal-Based Classifications of Neurons and Microglia in Two and Three Dimensions.Advances in neurobiology · 2024Review
- The PrLiScience · 2023Article
- GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Effects of social rank and pubertal delay on brain structure in female rhesus macaques.Psychoneuroendocrinology · 2023Article
- Prefrontal modulation of anxiety through a lens of noradrenergic signaling.Frontiers in systems neuroscience · 2023Review
- Glucocorticoid regulation of diurnal spine plasticity in the murine ventromedial prefrontal cortex.Journal of neuroendocrinology · 2022Article
- Activity in a prefrontal-periaqueductal gray circuit overcomes behavioral and endocrine features of the passive coping stress response.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Medial orbitofrontal neurotrophin systems integrate hippocampal input into outcome-specific value representations.Cell reports · 2022Article
- A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory.Nature neuroscience · 2022Article
- Synaptic Mechanisms Regulating Mood State Transitions in Depression.Annual review of neuroscience · 2022Review
17 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
Activation of the hypothalamo-pituitary-adrenal (HPA) axis plays a vital role in promoting adaptation during acute stress, but adverse effects of chronic stress may result from overactivity of this system. Recent evidence highlights a subdivision of GABAergic neurons within anterior bed nuclei of the stria terminalis (aBST) that integrates and relays inhibitory influences to HPA-effector neurons in paraventricular hypothalamus during acute stress, notably from medial prefrontal [prelimbic (PL)] and hippocampal [ventral subiculum (vSUB)] cortical fields. Here we localize the site and candidate mechanism of neuroplasticity within upstream regions of this inhibitory network after chronic variable stress (CVS). Rats bearing retrograde tracer injections in aBST underwent CVS for 14 d. Retrogradely labeled and unlabeled neurons in vSUB and PL were selected for intracellular dye filling, followed by three-dimensional imaging and analysis of dendritic arborization and spine morphometry. Whereas PL neurons displayed decreases in dendritic branching and spine density after CVS, aBST-projecting cells showed a selective loss of mature mushroom-shaped spines. In a follow-up experiment, CVS-treated and control rats were exposed to a novel restraint challenge for assay of HPA activation and engagement of aBST-projecting cortical regions. CVS animals showed enhanced HPA output and decreased Fos activation in aBST-projecting PL neurons compared with acutely stressed controls. In contrast, vSUB failed to show any significant differences in structural plasticity or functional activation patterns after CVS. These findings define a mechanism whereby synaptic destabilization in the PL → aBST pathway may dampen its ability to impart inhibitory control over the HPA axis after chronic stress exposure.
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