ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Assignment of model amygdala neurons to the fear memory trace depends on competitive synaptic interactions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Engrams and Memory: My Scientific "Eras Tour".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Role of Intrinsic Plasticity in Engram Physiology and Temporal Memory Linking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- The Role of Prefrontal Ensembles in Memory Across Time: Time-Dependent Transformations of Prefrontal Memory Ensembles.Advances in neurobiology · 2024Review
- Inhibitory circuits in fear memory and fear-related disorders.Frontiers in neural circuits · 2023Review
- The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating.Neurobiology of learning and memory · 2020Review
- Low-threshold spiking interneurons perform feedback inhibition in the lateral amygdala.Brain structure & function · 2020Article
- Memory engrams: Recalling the past and imagining the future.Science (New York, N.Y.) · 2020Review
- The Interplay of Synaptic Plasticity and Scaling Enables Self-Organized Formation and Allocation of Multiple Memory Representations.Frontiers in neural circuits · 2020Article
- Neurophotonics Approaches for the Study of Pattern Separation.Frontiers in neural circuits · 2020Review
- Neuronal competition: microcircuit mechanisms define the sparsity of the engram.Current opinion in neurobiology · 2019Review
- A model of amygdala function following plastic changes at specific synapses during extinction.Neurobiology of stress · 2019Article
- Maintenance of postsynaptic neuronal excitability by a positive feedback loop of postsynaptic BDNF expression.Cognitive neurodynamics · 2018Article
- Memory Allocation: Mechanisms and Function.Annual review of neuroscience · 2018Review
- Symmetry of learning rate in synaptic plasticity modulates formation of flexible and stable memories.Scientific reports · 2017Article
- Mechanisms of memory storage in a model perirhinal network.Brain structure & function · 2017Article
- Article
- Distinct current modules shape cellular dynamics in model neurons.Neuroscience · 2016Article
- Surface expression of hippocampal NMDA GluN2B receptors regulated by fear conditioning determines its contribution to memory consolidation in adult rats.Scientific reports · 2016Article
- Competition between engrams influences fear memory formation and recall.Science (New York, N.Y.) · 2016Article
- Mechanisms underlying the formation of the amygdalar fear memory trace: A computational perspective.Neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We used biophysical modeling to examine a fundamental, yet unresolved, question regarding how particular lateral amygdala (LA) neurons are assigned to fear memory traces. This revealed that neurons with high intrinsic excitability are more likely to be integrated into the memory trace, but that competitive synaptic interactions also play a critical role. Indeed, when the ratio of intrinsically excitable cells was increased or decreased, the number of plastic cells remained relatively constant. Analysis of the connectivity of plastic and nonplastic cells revealed that subsets of principal LA neurons effectively band together by virtue of their excitatory interconnections to suppress plasticity in other principal cells via the recruitment of inhibitory interneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.