Evidence map›Paper›PMID 24005053›Full record

ArticleThe Journal of investigative dermatology2014

Identifying a hyperkeratosis signature in autosomal recessive congenital ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model.

Gehad Youssef, Masahiro Ono, Stuart J Brown, Veronica A Kinsler, Neil J Sebire, John I Harper, Ryan F L O'Shaughnessy

Abstract readLetter
PubMed Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gehad YoussefLivingstone Skin Research Centre, Institute of Child Health, UCL, London, UK; Immunobiology and Dermatology, Institute of Child Health, UCL, London, UK.
Masahiro OnoImmunobiology and Dermatology, Institute of Child Health, UCL, London, UK.
Stuart J BrownLivingstone Skin Research Centre, Institute of Child Health, UCL, London, UK; Immunobiology and Dermatology, Institute of Child Health, UCL, London, UK.
Veronica A KinslerLivingstone Skin Research Centre, Institute of Child Health, UCL, London, UK; Clinical and Molecular Genetics Unit, Institute of Child Health, UCL, London, UK.
Neil J SebireHistopathology, Great Ormond Street Hospital, London, UK.
John I HarperLivingstone Skin Research Centre, Institute of Child Health, UCL, London, UK; Immunobiology and Dermatology, Institute of Child Health, UCL, London, UK.
Ryan F L O'ShaughnessyLivingstone Skin Research Centre, Institute of Child Health, UCL, London, UK; Immunobiology and Dermatology, Institute of Child Health, UCL, London, UK. Electronic address: r.oshaughnessy@ucl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsDisease Models, AnimalGenes, RecessiveHumansIchthyosis, LamellarImidazolesKeratosisOrgan Culture TechniquesPiperazinesProto-Oncogene Proteins c-mdm2RatsSkinImidazolesMdm2 protein, ratnutlin 3PiperazinesProto-Oncogene Proteins c-mdm2

Identifiers

PMID24005053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.