Trial reportAmerican journal of hypertension2014
Blood pressure responses to dietary sodium and potassium interventions and the cold pressor test: the GenSalt replication study in rural North China.
Trial report in American journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Meta-Analysis of Effect of Dietary Salt Restriction on Blood Pressure in Chinese Adults.Global heart · 2015Pooled it
- A Dietary Intervention in Urban African Americans: Results of the "Five Plus Nuts and Beans" Randomized Trial.American journal of preventive medicine · 2016Trial
- Effect of Yogurt Intake Frequency on Blood Pressure: A Cross-Sectional Study.International journal of hypertension · 2024Article
- Sodium sensitivity of blood pressure in Chinese populations.Journal of human hypertension · 2020Review
- 2018 Chinese Guidelines for Prevention and Treatment of Hypertension-A report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension.Journal of geriatric cardiology : JGC · 2019Article
- Relationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkers.Industrial health · 2016Article
- Salt reduction and hypertension in China: a concise state-of-the-art review.Cardiovascular diagnosis and therapy · 2015Review
- Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.Circulation. Cardiovascular genetics · 2013Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundIn the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study, we observed that blood pressure (BP) responses to dietary sodium and potassium interventions and the cold pressor test (CPT) varied greatly among individuals. We conducted a replication study to confirm our previous findings among 695 study participants.
methodsThe dietary intervention included a 7-day low sodium (51.3 mmol/day), a 7-day high sodium (307.8 mmol/day), and a 7-day high sodium with potassium supplementation (307.8 mmol sodium and 60 mmol potassium/day). BP measurements were obtained during the baseline and each intervention phase. During the CPT, BP was measured before and at 0, 1, 2, and 4 minutes after the participants immersed their right hand in ice water for 1 minute.
resultsSystolic and diastolic BP responses (mean ± SD (range), mm Hg) were 8.1±8.4 (-39.1 to 18.2) and -3.5±5.1 (-25.1 to 11.1) to low sodium, 9.1±8.4 (-13.3 to 33.1) and 4.0±5.4 (-16.0 to 20.7) to high sodium, and -4.6±5.8 (-31.8 to 11.6) and -1.9±4.3 (-16.9 to 14.2) to potassium supplementation, respectively (all P < 0.0001 for comparison with each former phase). The mean maximum systolic and diastolic BP responses to the CPT were 16.5±10.5 (-15.3 to 63.3) and 7.6±6.1 (-8.7 to 39.3), respectively (all P < 0.0001).
conclusionsOur study indicates that there are large variations in BP responses to dietary sodium and potassium interventions and to the CPT among individuals.
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