ReviewBritish journal of pharmacology2014
Bioenergetic medicine.
Review in British journal of pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer's disease: A randomized controlled trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Shifts in immunometabolism in autoimmune diseases.Immunologic research · 2026Review
- Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View.International journal of molecular sciences · 2024Article
- Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models.International journal of molecular sciences · 2023Review
- Investigating the role of body force or strength (Quwa) in causing diseases in Iranian traditional medicine and the role of cellular energy in causing diseases in conventional medicine.Journal of family medicine and primary care · 2022Review
- Pharmacologic enrichment of exosome yields and mitochondrial cargo.Mitochondrion · 2022Article
- Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Measurement of Mitochondrial Respiration in Platelets.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The mitochondrial hypothesis: Dysfunction, bioenergetic defects, and the metabolic link to Alzheimer's disease.International review of neurobiology · 2020Review
- Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities.British journal of pharmacology · 2019Review
- Mitochondria and Mitochondrial Cascades in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Review
- Metabolic Profiles Associated With Metformin Efficacy in Cancer.Frontiers in endocrinology · 2018Review
- Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2018Article
- A bioenergetics systems evaluation of ketogenic diet liver effects.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017Article
- Mitochondria, Cybrids, Aging, and Alzheimer's Disease.Progress in molecular biology and translational science · 2017Review
- A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer's Disease Subjects: Results of a Single-Arm, Pilot Trial.Journal of Alzheimer's disease : JAD · 2017Article
- Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer's Disease.Molecular neurobiology · 2016Article
- Bioenergetics and metabolism: a bench to bedside perspective.Journal of neurochemistry · 2016Review
- Tolerability and pharmacokinetics of oxaloacetate 100 mg capsules in Alzheimer's subjects.BBA clinical · 2016Article
- Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers.Journal of Alzheimer's disease : JAD · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Here we discuss a specific therapeutic strategy we call 'bioenergetic medicine'. Bioenergetic medicine refers to the manipulation of bioenergetic fluxes to positively affect health. Bioenergetic medicine approaches rely heavily on the law of mass action, and impact systems that monitor and respond to the manipulated flux. Since classically defined energy metabolism pathways intersect and intertwine, targeting one flux also tends to change other fluxes, which complicates treatment design. Such indirect effects, fortunately, are to some extent predictable, and from a therapeutic perspective may also be desirable. Bioenergetic medicine-based interventions already exist for some diseases, and because bioenergetic medicine interventions are presently feasible, new approaches to treat certain conditions, including some neurodegenerative conditions and cancers, are beginning to transition from the laboratory to the clinic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.