Evidence map›Paper›PMID 24004284›Full record

ArticleInorganic chemistry2013

Generation of high-spin iron(I) in a protein environment using cryoreduction.

Roman M Davydov, Matthew P McLaughlin, Eckhard Bill, Brian M Hoffman, Patrick L Holland

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Roman M DavydovDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
Matthew P McLaughlin
Eckhard Bill
Brian M Hoffman
Patrick L Holland
Northwestern University · USUniversity of Rochester · USMax Planck Institute for Chemical Energy Conversion · DE

Funding

COBOGLOBINS: COBALT-SUBSTITUTED MYO- AND HEMOGLOBINSR01HL013531 · NHLBI · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 1985 to 2013
$7.7M
Low-Coordinate Synthetic Models for Nitrogenase ActivityR01GM065313 · NIGMS · YALE UNIVERSITY · PI PATRICK L HOLLAND · 2004 to 2026
$6.4M
COBOGLOBINS: COBALT-SUBSTITUTED MYO- AND HEMOGLOBINSR37HL013531 · NHLBI · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 1989 to 1998
–
NHLBI NIH HHS HL13531NHLBI NIH HHS R01 HL013531NIGMS NIH HHS GM065313NIGMS NIH HHS R01 GM065313
6 · The paper itself

Abstract

High-spin Fe(1+) sites are potentially important in iron-sulfur proteins but are rare in synthetic compounds and unknown in metalloproteins. Here, we demonstrate a spectroscopically characterized example of high-spin non-heme Fe(1+) in a protein environment. Cryoreduction of Fe(2+)-substituted azurin at 77 K with (60)Co γ radiation generates a new species with a S = (3)/2 (high-spin) Fe(1+) center having D > 0 and E/D ~ 0.25. This transient species is stable in a glycerol-water glass only up to ~170 K. A combination of electron paramagnetic resonance and Mössbauer spectroscopies provides a powerful means of identifying a transient high-spin Fe(1+) site in a protein scaffold.

Indexed as

AzurinBacterial ProteinsCationsGlycerolIronModels, MolecularOxidation-ReductionPseudomonas aeruginosaTemperatureWaterAzurinBacterial ProteinsCationsGlycerolIronWater

Identifiers

PMID24004284
PMCPMC3767189
OpenAlexW2040492396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.