ArticleTissue engineering. Part A2014
Effects of biologic scaffolds on human stem cells and implications for CNS tissue engineering.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 102 citations in OpenAlex.
- Decellularized rat brain extracellular matrix effectively induces the dopaminergic differentiation of human adipose-derived stem cells.PloS one · 2025Article
- Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage.Biomaterials research · 2025Article
- 3D biological scaffold delivers Bergenin to reduce neuroinflammation in rats with cerebral hemorrhage.Journal of translational medicine · 2024Article
- The Effect of Multilayered Electrospun PLLA Nanofibers Coated with Human Amnion or Bladder ECM Proteins on Epithelialization and Smooth Muscle Regeneration in the Rabbit Bladder.Macromolecular bioscience · 2024Article
- Hydrogel in the Treatment of Traumatic Brain Injury.Biomaterials research · 2024Review
- Galactosylation of rat natural scaffold for MSC differentiation into hepatocyte-like cells: A comparative analysis of 2D vs. 3D cell culture techniques.Biochemistry and biophysics reports · 2023Article
- Collagen and Beyond: A Comprehensive Comparison of Human ECM Properties Derived from Various Tissue Sources for Regenerative Medicine Applications.Journal of functional biomaterials · 2023Article
- Development of Brain-Derived Bioscaffolds for Neural Progenitor Cell Culture.ACS pharmacology & translational science · 2023Article
- Neural progenitor cell-derived extracellular matrix as a new platform for neural differentiation of human induced pluripotent stem cells.Biomaterials and biosystems · 2022Article
- Tissue-Engineered Models of the Human Brain: State-of-the-Art Analysis and Challenges.Journal of functional biomaterials · 2022Review
- 3D-Printing Graphene Scaffolds for Bone Tissue Engineering.Pharmaceutics · 2022Review
- Decellularised extracellular matrix-based biomaterials for repair and regeneration of central nervous system.Expert reviews in molecular medicine · 2022Review
- Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications.International journal of biomaterials · 2022Review
- Organs-on-chips: into the next decade.Nature reviews. Drug discovery · 2021Review
- Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology.Micromachines · 2021Review
- Mesenchymal Stem Cells in Treatment of Spinal Cord Injury and Amyotrophic Lateral Sclerosis.Frontiers in cell and developmental biology · 2021Review
- Decellularization of Nervous Tissues and Clinical Application.Advances in experimental medicine and biology · 2021Article
- A State-of-the-Art of Functional Scaffolds for 3D Nervous Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2021Review
- Characterization of Porcine Urinary Bladder Matrix Hydrogels from Sodium Dodecyl Sulfate Decellularization Method.Polymers · 2020Article
- Role of Region-Specific Brain Decellularized Extracellular Matrix onTissue engineering. Part A · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Biologic scaffolds composed of mammalian extracellular matrix (ECM) promote constructive remodeling of tissues via mechanisms that include the recruitment of endogenous stem/progenitor cells, modulation of the host innate immune response, and influence of cell fate differentiation. Such scaffold materials are typically prepared by decellularization of source tissues and are prepared as sheets, powder, or hydrogels. It is plausible that ECM derived from an anatomically distinct tissue would have unique or specific effects on cells that naturally reside in this same tissue. The present study investigated the in vitro effect of a soluble form of ECM derived from central nervous system (CNS) tissue, specifically the spinal cord or brain, versus ECM derived from a non-CNS tissue; specifically, the urinary bladder on the behavior of neural stem cells (NSCs) and perivascular stem cells. All forms of ECM induce positive, mitogenic, and chemotactic effects at concentrations of approximately 100 μg/mL without affecting stem cell viability. CNS-derived ECMs also showed the ability to differentiate NSCs into neurons as indicted by βIII-tubulin expression in two-dimensional culture and neurite extension on the millimeter scale after 24 days of three-dimensional cultures in an ECM hydrogel. These results suggest that solubilized forms of ECM scaffold materials may facilitate the postinjury healing response in CNS tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.