Evidence map›Paper›PMID 24003930›Full record

ReviewDiabetes, obesity & metabolism2013

Islet autoimmunity in phenotypic type 2 diabetes patients.

B Brooks-Worrell, R Narla, J P Palmer

Open access · bronzeAbstract readReview
In one paragraph

Review in Diabetes, obesity & metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Type 2 Diabetes: How Much of an Autoimmune Disease?Frontiers in endocrinology · 2019
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Serum Metrnl Level is Correlated with Insulin Resistance, But Not with β-Cell Function in Type 2 Diabetics.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. ER stress and development of type 1 diabetes.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016
    Review
  19. Hyaluronan: A Mediator of Islet Dysfunction and Destruction in Diabetes?The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

B Brooks-WorrellDepartment of Medicine, University of Washington, Seattle, WA, USA. bbrooks@u.washington.edu
R Narla
J P Palmer
University of Washington · USVA Puget Sound Health Care System · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Julie Mathieu · 1986 to 2026
$41.4M
Identification of Islet Proteins Stimulatory for T Cells from Diabetes PatientsR01DK083471 · NIDDK · UNIVERSITY OF WASHINGTON · PI PALMER, JERRY P · 2010 to 2013
$1.5M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK083471
6 · The paper itself

Abstract

Historically, type 2 diabetes (T2D) was considered a metabolic disease of ageing. However, recent discoveries have demonstrated the role of chronic systemic inflammation in the development of insulin resistance and subsequent progression to T2D. Over the years, investigations into the pathophysiology of T2D have identified the presence of islet-specific T cells and islet autoimmune disease in T2D patients. Moreover, the cell-mediated islet autoimmunity has also been correlated with the progressive loss of β-cell function associated with T2D disease pathogenesis. In this manuscript, the involvement of cell-mediated islet autoimmune disease in the progression of T2D disease and the similarities in islet-specific T-cell reactivity between type 1 diabetes (T1D) and T2D are discussed.

Indexed as

AutoantibodiesAutoimmunityDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2HumansIslets of LangerhansPhenotypeT-LymphocytesAutoantibodiesautoimmune diseaseautoimmunityinflammationislet-reactive T cellsT cellstype 1 diabetestype 2 diabetes

Identifiers

PMID24003930
PMCPMC4260534
OpenAlexW2046169514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.