ArticleThe Journal of biological chemistry2013
The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- The Multifaceted Interactions ofCells · 2024Article
- Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice.iScience · 2023Article
- Eukaryotic translation initiation factor 3 subunit B could serve as a potential prognostic predictor for breast cancer.Bioengineered · 2022Article
- H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.Journal of cachexia, sarcopenia and muscle · 2021Article
- Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.Developmental cell · 2021Article
- eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease.Journal of molecular cell biology · 2020Review
- Review
- In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation.Molecular therapy. Nucleic acids · 2020Article
- Roles of eIF3m in the tumorigenesis of triple negative breast cancer.Cancer cell international · 2020Article
- High expression of eukaryotic initiation factor 3M predicts poor prognosis in colon adenocarcinoma patients.Oncology letters · 2020Article
- Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance.BMC developmental biology · 2018Article
- Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation.FEBS open bio · 2018Article
- eIF3: a factor for human health and disease.RNA biology · 2018Review
- Translational Control in Stem Cells.Frontiers in genetics · 2018Review
- The eIF3 complex ofRNA (New York, N.Y.) · 2017Article
- Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer.Nucleic acids research · 2016Article
- Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion.Structure (London, England : 1993) · 2016Article
- Functional and biochemical characterization of human eukaryotic translation initiation factor 3 in living cells.Molecular and cellular biology · 2014Article
- The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.Nature cell biology · 2013Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian eIF3 is composed of 13 subunits and is the largest eukaryotic initiation factor. eIF3 plays a key role in protein biosynthesis. However, it is not fully understood how different subunits contribute to the structural integrity and function of the eIF3 complex. Whether eIF3 is essential for embryonic development and homeostasis is also not known. Here, we show that eIF3m null embryos are lethal at the peri-implantation stage. Compound heterozygotes (eIF3m(flox)(/-)) or FABP4-Cre-mediated conditional knock-out mice are lethal at mid-gestation stages. Although the heterozygotes are viable, they show markedly reduced organ size and diminished body weight. Acute ablation of eIF3m in adult mouse liver leads to rapidly decreased body weight and death within 2 weeks; these effects are correlated with a severe decline of protein biogenesis in the liver. Protein analyses reveal that eIF3m deficiency significantly impairs the integrity of the eIF3 complex due to down-regulation of multiple other subunits. Two of the subunits, eIF3f and eIF3h, are stabilized by eIF3m through subcomplex formation. Therefore, eIF3m is required for the structural integrity and translation initiation function of eIF3. Furthermore, not only is eIF3m an essential gene, but its expression level is also important for mouse embryonic development and the control of organ size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.