Evidence map›Paper›PMID 24003213›Full record

ReviewCold Spring Harbor perspectives in biology2013

Nucleosome remodeling and epigenetics.

Peter B Becker, Jerry L Workman

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Review
  8. Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Epigenetic crosstalk in neuroblastoma development and progression.Frontiers in cell and developmental biology · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. NuRD chromatin remodeling is required to repair exogenous DSBs in thebioRxiv : the preprint server for biology · 2025
    Article
  19. Review
  20. Article

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peter B BeckerBioMedical Center, Ludwig-Maximilians-University, D-80336 Munich, Germany. pbecker@med.uni-muenchen.de
Jerry L Workman

Funding

Mechanisms of Transcriptional Regulation in ChromatinR37GM047867 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI WORKMAN, JERRY L · 2001 to 2010
$3.4M
MECHANISMS OF TRANSCRIPTIONAL REGULATION IN CHROMATINR01GM047867 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI WORKMAN, JERRY L · 1992 to 2014
$1.5M
Analysis of metazoan SAGA complex function in gene expressionR01GM099945 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI ABMAYR, SUSAN M, WORKMAN, JERRY L · 2012 to 2015
$1.2M
NIGMS NIH HHS GM047867NIGMS NIH HHS GM99945NIGMS NIH HHS R01 GM047867NIGMS NIH HHS R01 GM099945NIGMS NIH HHS R37 GM047867
6 · The paper itself

Abstract

Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic, and developmental cues through the action of a family of so-called "nucleosome remodeling" ATPases. Consistent with their helicase ancestry, these enzymes experience conformation changes as they bind and hydrolyze ATP. At the same time they interact with DNA and histones, which alters histone-DNA interactions in target nucleosomes. Their action may lead to complete or partial disassembly of nucleosomes, the exchange of histones for variants, the assembly of nucleosomes, or the movement of histone octamers on DNA. "Remodeling" may render DNA sequences accessible to interacting proteins or, conversely, promote packing into tightly folded structures. Remodeling processes participate in every aspect of genome function. Remodeling activities are commonly integrated with other mechanisms such as histone modifications or RNA metabolism to assemble stable, epigenetic states.

Indexed as

Models, BiologicalAdenosine TriphosphateChromatinDNA MethylationEpigenesis, GeneticGene Expression RegulationHistonesMi-2 Nucleosome Remodeling and Deacetylase ComplexNucleosomesAdenosine TriphosphateChromatinHistonesMi-2 Nucleosome Remodeling and Deacetylase ComplexNucleosomes

Identifiers

PMID24003213
PMCPMC3753709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.