ArticleProceedings of the National Academy of Sciences of the United States of America2013
Physiological, anatomical, and behavioral changes after acoustic trauma in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- AFrontiers in cell and developmental biology · 2022Article
- Gene transcription changes in a locust model of noise-induced deafness.Journal of neurophysiology · 2021Article
- Article
- Environmental cue affects the hearing-related behaviors of Drosophila melanogaster by targeting the redox pathways.Environmental science and pollution research international · 2020Article
- Homeostatic maintenance and age-related functional decline in the Drosophila ear.Scientific reports · 2020Article
- Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hearing in Drosophila.Current opinion in neurobiology · 2015Review
- Article
- Noise-induced hearing loss: new animal models.Current opinion in otolaryngology & head and neck surgery · 2014Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Noise-induced hearing loss (NIHL) is a growing health issue, with costly treatment and lost quality of life. Here we establish Drosophila melanogaster as an inexpensive, flexible, and powerful genetic model system for NIHL. We exposed flies to acoustic trauma and quantified physiological and anatomical effects. Trauma significantly reduced sound-evoked potential (SEP) amplitudes and increased SEP latencies in control genotypes. SEP amplitude but not latency effects recovered after 7 d. Although trauma produced no gross morphological changes in the auditory organ (Johnston's organ), mitochondrial cross-sectional area was reduced 7 d after exposure. In nervana 3 heterozygous flies, which slightly compromise ion homeostasis, trauma had exaggerated effects on SEP amplitude and mitochondrial morphology, suggesting a key role for ion homeostasis in resistance to acoustic trauma. Thus, Drosophila exhibit acoustic trauma effects resembling those found in vertebrates, including inducing metabolic stress in sensory cells. This report of noise trauma in Drosophila is a foundation for studying molecular and genetic sequelae of NIHL.
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Registered trials
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