ArticleProceedings of the National Academy of Sciences of the United States of America2013
Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism.Scientific reports · 2017Pooled it
- Hunger recruits a parallel circuit encoding alcohol reward.Current biology : CB · 2026Article
- Article
- Molecular evolution of octopamine receptors in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- Structural insights into endogenous agonist selectivity of aminergic receptors from the octopamine βPNAS nexus · 2025Article
- Molecular evolution of octopamine receptors inbioRxiv : the preprint server for biology · 2025Article
- Hunger Recruits a Parallel Circuit Encoding Alcohol Reward.bioRxiv : the preprint server for biology · 2025Article
- Regulation of forager honey bee appetite independent of the glucose-insulin signaling pathway.Frontiers in insect science · 2024Article
- Search performance and octopamine neuronal signaling mediate parasitoid induced changes in Drosophila oviposition behavior.Nature communications · 2022Article
- Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression.Cellular and molecular life sciences : CMLS · 2022Review
- Survey of neurotransmitter receptor gene expression into and out of parental care in the burying beetleEcology and evolution · 2021Article
- Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis inLife science alliance · 2021Article
- Article
- Review
- Article
- Neural basis of hunger-driven behaviour in Drosophila.Open biology · 2019Review
- Regulation of Feeding and Metabolism by Neuropeptide F and Short Neuropeptide F in Invertebrates.Frontiers in endocrinology · 2019Review
- Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors.Neuroscience bulletin · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The easy accessibility of energy-rich palatable food makes it difficult to resist food temptation. Drosophila larvae are surrounded by sugar-rich food most of their lives, raising the question of how these animals modulate food-seeking behaviors in tune with physiological needs. Here we describe a circuit mechanism defined by neurons expressing tdc2-Gal4 (a tyrosine decarboxylase 2 promoter-directed driver) that selectively drives a distinct foraging strategy in food-deprived larvae. Stimulation of this otherwise functionally latent circuit in tdc2-Gal4 neurons was sufficient to induce exuberant feeding of liquid food in fed animals, whereas targeted lesions in a small subset of tdc2-Gal4 neurons in the subesophageal ganglion blocked hunger-driven increases in the feeding response. Furthermore, regulation of feeding rate enhancement by tdc2-Gal4 neurons requires a novel signaling mechanism involving the VEGF2-like receptor, octopamine, and its receptor. Our findings provide fresh insight for the neurobiology and evolution of appetitive motivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.