ArticleProceedings of the National Academy of Sciences of the United States of America2013
Integration of epigenetic and genetic controls of seed size by cytokinin in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Role of cytokinins in seed development in pulses and oilseed crops: Current status and future perspective.Frontiers in genetics · 2022Pooled it
- Distinct associations of ScGDD1/BC12 transcript abundance and sequence variation with grain size and shape in rye.Journal of applied genetics · 2026Article
- The IKU2/RLK7-MAPK-MINI3 signaling module controls endosperm cellularization timing to determine seed size in Arabidopsis.Journal of integrative plant biology · 2026Article
- TIE1 acts as a maternal brake on fertilization-independent endosperm development by associating with PRC2 to enforce imprinting.Nature plants · 2026Article
- Large-scale screening of genes responsible for silique length and seed size in Brassica Napus via pooled CRISPR library.BMC genomics · 2025Article
- The role of cytokinin receptors in Arabidopsis thaliana seed development and how they affect the metabolomic profile.Planta · 2025Article
- Decoding hybridization barriers: the molecular and genetic orchestration of the triploid block in Arabidopsis thaliana.BMC plant biology · 2025Review
- Genetic analysis of silique and seed traits in Brassica juncea (L.) Czern. under differential doses of nitrogen application.Scientific reports · 2025Article
- Molecular Characterization of Cytokinin Response Regulator ARR21 inPlant direct · 2025Article
- Hormonal regulation and crosstalk during early endosperm and seed coat development.Plant reproduction · 2024Review
- Epigenetics and plant hormone dynamics: a functional and methodological perspective.Journal of experimental botany · 2024Review
- Article
- When Size Matters: New Insights on How Seed Size Can Contribute to the Early Stages of Plant Development.Plants (Basel, Switzerland) · 2024Review
- Phenotypic characterization and candidate gene analysis of a short kernel and brassinosteroid insensitive mutant from hexaploid oat (Frontiers in plant science · 2024Article
- Analysis of Genetic Diversity in Adzuki Beans (Plants (Basel, Switzerland) · 2023Article
- Molecular Network for Regulation of Seed Size in Plants.International journal of molecular sciences · 2023Review
- Control of ovule development inHorticulture research · 2023Article
- Genetic Localization and Homologous Genes Mining for Barley Grain Size.International journal of molecular sciences · 2023Review
- Molecular, genetic, and genomic basis of seed size and yield characteristics in soybean.Frontiers in plant science · 2023Review
- Transcriptome analysis reveals cell cycle-related transcripts as key determinants of varietal differences in seed size of Brassica juncea.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of seeds in flowering plants is placed under complex interactions between maternal tissues, the embryo, and the endosperm. The endosperm plays a major role in the regulation of seed size. In Arabidopsis thaliana, endosperm size depends on the coordination of the genetic pathway HAIKU (IKU) with epigenetic controls comprising genome dosage, DNA methylation, and trimethylated lysine 27 on histone H3 (H3K27me3) deposition. However, the effectors that integrate these pathways have remained unknown. Here, we identify a target of the IKU pathway, the cytokinin oxidase CKX2, that affects cytokinin signaling. CKX2 expression is activated by the IKU transcription factor WRKY10 directly and promotes endosperm growth. CKX2 expression also depends on H3K27me3 deposition, which fluctuates in response to maternal genome dosage imbalance and DNA demethylation of male gametes. Hence, the control of endosperm growth by CKX2 integrates genetic and epigenetic regulations. In angiosperms, cytokinins are highly active in endosperm, and we propose that IKU effectors coordinate environmental and physiological factors, resulting in modulation of seed size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.