ArticleG3 (Bethesda, Md.)2013
Genetic background and GxE interactions modulate the penetrance of a naturally occurring wing mutation in Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model.Cell genomics · 2026Article
- AntagonizingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome.Frontiers in immunology · 2021Article
- Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression.Trends in genetics : TIG · 2018Review
- Energy demand and the context-dependent effects of genetic interactions underlying metabolism.Evolution letters · 2018Article
- Genetic backgrounds and hidden trait complexity in natural populations.Current opinion in genetics & development · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Many genes involved in producing complex traits are incompletely penetrant. One such example is vesiculated, an X-linked gene in Drosophila melanogaster that results in wing defects. To examine the genetic architecture of a complex trait (wings containing vesicles), we placed a naturally occurring variant into multiple autosomal backgrounds and quantified penetrance and expressivity at a range of developmental temperatures. We found significant epistasis, genotype-by-environment interactions, and maternal effects. Sex and temperature effects were modulated by genetic background. The severity of wing phenotypes also varied across different genetic backgrounds, and expressivity was positively correlated with penetrance. We also found evidence of naturally segregating suppressors of vesiculated. These suppressors were present on both the second and third chromosomes, and complex interactions were observed. Taken together, these findings indicate that multiple genetic and environmental factors modulate the phenotypic effects of a naturally occurring vesiculated allele.
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Registered trials
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