ArticleInternal and emergency medicine2014
Guidance for diagnosis and treatment of acute angioedema in the emergency department: consensus statement by a panel of Italian experts.
Article in Internal and emergency medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- The 2025 WAO Guidelines for the classification, diagnosis, and treatment of hereditary angioedema, with consideration of worldwide disparities.The World Allergy Organization journal · 2026Article
- The characteristics of upper airway edema in hereditary and acquired angioedema with C1-inhibitor deficiency.Clinical and translational allergy · 2021Article
- Differences and Similarities in the Mechanisms and Clinical Expression of Bradykinin-Mediated vs. Mast Cell-Mediated Angioedema.Clinical reviews in allergy & immunology · 2021Review
- Hereditary angioedema: how to approach it at the emergency department?Einstein (Sao Paulo, Brazil) · 2021Article
- Clinical Features and Outcomes Associated with Angioedema in the Emergency Department.The western journal of emergency medicine · 2019Article
- Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Article
- Value co-creation in healthcare: evidence from innovative therapeutic alternatives for hereditary angioedema.BMC health services research · 2018Article
- Angioedema in the emergency department: a practical guide to differential diagnosis and management.International journal of emergency medicine · 2017Review
- Angioedema.Deutsches Arzteblatt international · 2017Review
- Drug-Induced Inhibition of Angiotensin Converting Enzyme and Dipeptidyl Peptidase 4 Results in Nearly Therapy Resistant Bradykinin Induced Angioedema: A Case Report.The American journal of case reports · 2017Article
- The Story of Angioedema: from Quincke to Bradykinin.Clinical reviews in allergy & immunology · 2016Review
- Review of Select Practice Parameters, Evidence-Based Treatment Algorithms, and International Guidelines for Hereditary Angioedema.Clinical reviews in allergy & immunology · 2016Review
- High attack frequency in patients with angioedema due to C1-inhibitor deficiency is a major determinant in switching to home therapy: a real-life observational study.Orphanet journal of rare diseases · 2016Article
- Article
- Management of urticaria: not too complicated, not too simple.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Review
- Treatment of ACEI-related angioedema with icatibant: a case series.Internal and emergency medicine · 2015Article
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angioedema attacks, characterized by the transient swelling of the skin and mucosae, are a frequent cause of visits to the emergency department. Swellings of the oral cavity, tongue, or larynx can result in life-threatening airway obstruction, while abdominal attacks can cause severe pain and often lead to unnecessary surgery. The underlying pathophysiologic process resulting in increased vascular permeability and plasma extravasation is mediated by vasoactive molecules, most commonly histamine and bradykinin. Based on the mediator involved, distinct angioedema forms can be recognized, calling for distinct therapeutic approaches. Prompt recognition is challenging for the emergency physician. The low awareness among physicians of the existence of rare forms of angioedema with different aetiologies and pathogenesis, considerably adds to the problem. Also poorly appreciated by emergency personnel may be the recently introduced bradykinin-targeted treatments. The main objective of this consensus statement is to provide guidance for the management of acute angioedema in the emergency department, from presentation to discharge or hospital admission, with a focus on identifying patients in whom new treatments may prevent invasive intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.