SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2013
The volume effect in liver surgery--a systematic review and meta-analysis.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Volume-outcome relationship in anatomical and non-anatomical liver resections: a rapid systematic review.BMC gastroenterology · 2026Pooled it
- Pooled it
- AFP Model Predicts Outcomes After Liver Resection: A Multicenter Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- Hospital surgical volume, perioperative transfusion, and 30-day mortality after pancreatic surgery: a nationwide population-based retrospective cohort study in South Korea.Annals of surgical treatment and research · 2026Article
- Hospital Volume and Post-Hepatectomy Liver Failure After Major Hepatectomy.Journal of surgical oncology · 2026Article
- Effect of Case Discussion with Expert Centers on Treatment Outcome of Intrahepatic Cholangiocarcinoma.Annals of surgical oncology · 2026Article
- Evaluation of the American College of Surgeons risk calculator in hepatectomy for metastatic colorectal cancer in a Southeast Asian population.Langenbeck's archives of surgery · 2024Article
- Hospital Volume and Textbook Outcomes in Minimally Invasive Hepatectomy for Hepatocellular Carcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Timing of Complication and Failure to Rescue after Hepatectomy: Single-Institution Analysis of 28 Years of Hepatic Surgery.Journal of the American College of Surgeons · 2021Article
- The Italian Consensus on minimally invasive simultaneous resections for synchronous liver metastasis and primary colorectal cancer: A Delphi methodology.Updates in surgery · 2021Article
- Surgical Therapy for Perihilar Cholangiocarcinoma: State of the Art.Visceral medicine · 2021Review
- Variation in complications and mortality following ALPPS at early-adopting centers.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2021Article
- Clinical outcomes after major hepatectomy are acceptable in low-volume centers in the Caribbean.World journal of hepatology · 2019Article
- Contemporary practice and short-term outcomes after liver resections in a complete national cohort.Langenbeck's archives of surgery · 2019Article
- Effects of patient factors on inpatient mortality after complex liver, pancreatic and gastric resections.BJS open · 2017Article
- Distance to Specialist Care and Disease Outcomes in Inflammatory Bowel Disease.Inflammatory bowel diseases · 2017Article
- Evaluating Trends in the Volume-Outcomes Relationship Following Liver Surgery: Does Regionalization Benefit All Patients the Same?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- Hospital Volume and Survival After Hepatocellular Carcinoma Diagnosis.The American journal of gastroenterology · 2016Article
- Surgical management of hepatocellular carcinoma.World journal of hepatology · 2015Review
- Volume-outcome associations after major hepatectomy for hepatocellular carcinoma: a nationwide Taiwan study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an inverse relationship between hospital and surgeon volume and mortality in many types of complex surgery. The aim of this paper is to investigate the volume effect on outcomes of liver surgery.
methodsA systematic review and meta-analysis was performed. A literature search was conducted using Medline and EMBASE from 1995 to 2012. A random effects model was used.
resultsSeventeen studies were selected for detailed analysis. Definition of a high-volume institution varied from 2 to more than 33 procedures per year. The pooled odds ratio of mortality rate in low- vs high-volume centres was 2.0 [95 % confidence interval (CI), 1.6-2.4; P < 0.001]. Some studies divided centres into more than two groups and compared the highest and lowest volume groups. The pooled odds ratio of mortality rate for this comparison type was 3.2 (95 % CI, 1.7-5.8; P < 0.001). Funnel plots suggest possible publication bias. There was inadequate data to compare morbidity. Only two of seven studies demonstrated a shorter length of stay in the high-volume centres. There was no convincing volume effect on long-term survival.
conclusionsThis study suggests a strong relationship between volume and perioperative mortality. No difference in morbidity, length of stay or survival was demonstrated.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.