ArticleBritish journal of cancer2013
The interaction between prognostic and pharmacodynamic biomarkers.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
backgroundInteractions between prognostic and pharmacodynamic (PD) biomarkers have received little attention.
methodsPrognostic and PD utilities were assessed with linear mixed-effects models using published data on repeated measurements of circulating caspase-cleaved (ctCK18) and total (tCK18) cytokeratin 18, in 57 patients with metastatic colorectal cancer undergoing chemotherapy.
resultsThe model for tCK18 (but not cCK18) separated the prognostic/PD interaction from the pure prognostic effect, illustrating the principle of dual prognostic and PD characteristics for a given biomarker.
conclusionThese models provide the framework for the analysis and interpretation of longitudinal data to detect prognostic/PD biomarker interactions.
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