ArticleEuropean journal of applied physiology2013
Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners.
Article in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 98 citations in OpenAlex.
- Effect of 6-week curcumin supplementation on aerobic capacity, antioxidant status and sirtuin 3 level in middle-aged amateur long-distance runners.Redox report : communications in free radical research · 2022Trial
- Trial
- The effect of vitamin D supplementation on serum total 25(OH) levels and biochemical markers of skeletal muscles in runners.Journal of the International Society of Sports Nutrition · 2020Trial
- Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners.Journal of the International Society of Sports Nutrition · 2019Trial
- Effect of Iron Supplementation on the Modulation of Iron Metabolism, Muscle Damage Biomarkers and Cortisol in Professional Cyclists.Nutrients · 2019Trial
- Acute Endocrine and Lipid Responses to Extreme Ultramarathon Running Across 100, 308, and 622 km Events.Life (Basel, Switzerland) · 2026Article
- Hematological and Biochemical Responses During and After a 12-h Track Ultra-Marathon Race.Journal of functional morphology and kinesiology · 2026Article
- Effect of 8 days of water-only fasting and exercise on liver, kidney and pancreas functions in middle-aged men.Scientific reports · 2025Article
- Inflammatory Response to Ultramarathon Running: A Review of IL-6, CRP, and TNF-α.International journal of molecular sciences · 2025Review
- Reversible reduction in brain myelin content upon marathon running.Nature metabolism · 2025Observational
- Race course characteristics are the most important predictors in 48 h ultramarathon running.Scientific reports · 2025Article
- Biomarkers of muscle damage and oxidative stress and biomechanical responses of two different advanced footwear technology shoes to a 60-min running test in competitive long-distance runners.Frontiers in physiology · 2025Article
- Impact of Genetic Polymorphisms on Electrochemical Parameters and Acid-Base Disorders in Brazilian Runners During a 105-Kilometer Ultramarathon.Nutrients · 2024Article
- Brainwave Patterns and Metabolic Adaptations in Rowers Crossing the Atlantic: A Case Series Pilot Study.Cureus · 2024Article
- Pre-Ride Biomarkers and Endurance Horse Welfare: Analyzing the Impact of the Elimination of Superoxide Dismutase, δ-Aminolevulinic-Dehydratase, Thiobarbituric Acid Reactive Substances, Iron, and Serum Amyloid A Levels in Elite 160 km Endurance Rides.Animals : an open access journal from MDPI · 2023Article
- Exercise-related changes in the anabolic index (testosterone to cortisol ratio) and serum amyloid A concentration in endurance and racehorses at different fitness levels.Frontiers in veterinary science · 2023Article
- Sustained Endurance Training Leads to Metabolomic Adaptation.Metabolites · 2022Article
- Potential Long-Term Health Problems Associated with Ultra-Endurance Running: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2022Review
- Extreme Ultra-Trail Race Induces Muscular Damage, Risk for Acute Kidney Injury and Hyponatremia: A Case Report.International journal of environmental research and public health · 2021Article
- Recommendations on Youth Participation in Ultra-Endurance Running Events: A Consensus Statement.Sports medicine (Auckland, N.Z.) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate ongoing metabolic changes during a 48-h competitive run and a 48-h recovery period, with focus on potential health risks exemplified by heart and skeletal muscle damage biomarkers and oxidative stress-related indices.
methodsBlood samples were taken before the race, after 12, 24, and 48 h of running, and after 24 and 48 h of recovery from male amateur runners (N = 7, age 35-59 years, VO2max mean ± SD 57.0 ± 4.0 ml kg(-1) min(-1), total distance covered 183-320 km). The samples were analyzed for morphology, acid-base and electrolyte balance, iron status, lipid profile, interleukin-6, high-sensitivity C-reactive protein, N-terminal pro-brain-type natriuretic peptide, high-sensitivity cardiac troponin T, non-enzymatic antioxidants, activities of selected enzymes including antioxidant enzymes, and total antioxidant status.
resultsThe sustained ultra-endurance run caused hypocapnic alkalosis with slight hyperkalemia and hypocalcemia, but no hyponatremia. Blood biochemistry showed severe muscle but not liver damage, and an acute inflammatory response. These effects were evidenced by leukocytosis, several fold rises in interleukin-6 and high sensitivity C-reactive protein, extreme elevations in serum levels of muscle enzymes, and marked increases in cardiac biomarker levels. Most of the changes dissolved during the 48 h post-race recovery. Neither the iron pool, nor erythropoiesis, nor pro-oxidant/antioxidant balance were substantially affected.
conclusionsThe changes consequent on the ultra-endurance run do not pose a serious health risk in men who begin their endeavor with ultra-endurance running in mid-life. There is some circumstantial evidence that hyperventilatory hypocapnia may modulate inflammatory response by stimulating the release of interleukin-6 from working skeletal muscles.
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