Trial reportMedical science monitor : international medical journal of experimental and clinical research2013
Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03674333 (Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
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- The impact of a superfood chocolate beverage on indices of peripheral vascular function.Physiological reports · 2025Article
- Assessment of cardiovascular risk factors and effect of lifestyle in individuals without cardiovascular disease, diabetes or chronic kidney disease.Scientific reports · 2025Article
- Heat syndrome types prediction of traditional Chinese medicine in acute ischemic stroke through deep learning: a pilot study.Frontiers in pharmacology · 2025Article
- Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia.Biomolecules · 2024Article
- The impact of lifestyle, measured with the HLPCQ questionnaire on the prevalence of metabolic syndrome in Poland: a multicenter study.Scientific reports · 2024Article
- Prevalence and predictors of low folate levels among stroke survivors in a country without mandatory folate food fortification: Analysis of a Ghanaian sample.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023Article
- Racial and rural-urban disparities in cardiovascular risk factors among patients with head and neck cancer in a clinical cohort.Head & neck · 2022Article
- Non-linear association between serum folate concentrations and dyslipidemia: Korea National Health and Nutrition Examination Survey 2016-2018.Epidemiology and health · 2022Article
- Effect of folic acid combined with pravastatin on arteriosclerosis in elderly hypertensive patients with lacunar infarction.Medicine · 2021Observational
- Serum Folate and All-Cause Mortality is of Non-Linear Relationship Among Population with Chronic Kidney Disease: A Retrospective Cohort Study.International journal of general medicine · 2021Article
- Red blood cell folate and cardiovascular deaths among hypertensive adults, an 18-year follow-up of a national cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Association between serum folate and cardiovascular deaths among adults with hypertension.European journal of clinical nutrition · 2020Article
- Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells.Molecular and cellular biochemistry · 2018Article
- Article
- Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro.International journal of molecular sciences · 2017Article
- A Simple Method for Optimization of Reference Gene Identification and Normalization in DNA Microarray Analysis.Medical science monitor basic research · 2016Article
- The Role of CD36 in the Effect of Arginine in Atherosclerotic Rats.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- A Snack Dietary Pattern Increases the Risk of Hypercholesterolemia in Northern Chinese Adults: A Prospective Cohort Study.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFolic acid (FA) is one of the B complex vitamins. It is thought that FA deficiency promotes atherosclerosis formation in arterial endothelium. FA, acting through reducing homocysteine (Hcy) levels, may contribute to decreased cholesterol (Ch) synthesis. The aim of this study was to analyze the association of low-dose folic acid supplementation with blood lipids concentrations in subjects with atherosclerosis risk factors. MATERIAL/
methodsThe study enrolled 124 Caucasian individuals (60 M, ages 20-39; and 64 F, ages 19-39) with atherosclerosis risk factors (family history of premature ischemic stroke, arterial hypertension, dyslipidemia, overweight and obesity, cigarette smoking, and low level of physical activity). The participants were asked to take FA at a low dose of 0.4 mg/24 h for 12 weeks.
resultsFA levels increased in females (6.3 vs. 12.5 ng/dL; p=0.001) and males (6.4 vs. 11.4 ng/dL; p=0.001) and Hcy levels decreased (10.6 vs. 8.3 µmol/L; p=0.001 and 11.5 vs. 9.3; p=0.001, respectively). A significant reduction in mean concentration of total cholesterol in females (203.4 vs. 193.1 mg/dL; p=0.001) and in males (209.5 vs. 201.9; p=0.002) was observed. The low-density lipoprotein cholesterol (LDL-C) levels decreased in females and in males (107.4 vs. 99.9 mg/dL; p=0.001 and 121.5 vs. 115.1; p=0.002, respectively). The apoAI concentrations increased in smoking women and in men with BMI≥25 kg/m2 (p=0.032 and p=0.024, respectively).
conclusionsLow-dose FA supplementation has a beneficial effect on blood lipids through decreasing concentrations of total cholesterol and LDL-C and increasing concentrations of apoAI.
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