Evidence map›Paper›PMID 24002237›Full record

ArticleAge and ageing2014

Association of stressful life events with incident falls and fractures in older men: the Osteoporotic Fractures in Men (MrOS) Study.

Howard A Fink, Michael A Kuskowski, Lynn M Marshall

Abstract readMulticenter Study
In one paragraph

Article in Age and ageing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Associations Between Multiple Falls and Mental Health Indices in Korean Older Adults: A Cross-sectional Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025
    Article
  6. Article
  7. Article
  8. Increased risk for hip fracture after death of a spouse-further support for bereavement frailty?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Article
  9. Article
  10. Article
  11. Perceived stress and risk of any osteoporotic fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
  12. Osteoporosis in men: findings from the Osteoporotic Fractures in Men Study (MrOS).Therapeutic advances in musculoskeletal disease · 2016
    Review
  13. Association of stressful life events with accelerated bone loss in older men: the osteoporotic fractures in men (MrOS) study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Howard A FinkVA Medical Center, Geriatric Research Education and Clinical Center, One Veterans Drive, 11-G, Minneapolis, MN 55417, USA.
Michael A Kuskowski
Lynn M Marshall

Funding

OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
OSTEOPOROTIC FRACTURES IN MENU01AG018197 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON · 1999 to 2011
$12.7M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
Osteoporotic Fractures in Men: MrOS Renewal-PortlandU01AR045647 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 1999 to 2011
$6.7M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Osteoporotic Fractures in Men - Renewal: PittsburghU01AR045654 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 1999 to 2011
$5.1M
OSTEOPOROTIC FRACTURES IN MENU01AR045614 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1999 to 2011
$4.0M
Osteoporotic Fractures in MenU01AR045583 · NIAMS · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L. · 1999 to 2011
$4.0M
Osteoporotic Fractures in Men - MrOS RenewalU01AR045580 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 1999 to 2011
$3.9M
Osteoporotic Fractures in Men- MrOS Renewal - BirminghamU01AR045632 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SHIKANY, JAMES M · 1999 to 2011
$3.6M
NCATS NIH HHS UL1 TR000128NCRR NIH HHS UL1 RR024140NIAMS NIH HHS U01 AR066160NIAMS NIH HHS U01 AR45580NIAMS NIH HHS U01 AR45583NIAMS NIH HHS U01 AR45614NIAMS NIH HHS U01 AR45632NIAMS NIH HHS U01 AR45647NIAMS NIH HHS U01 AR45654NIA NIH HHS U01 AG018197NIA NIH HHS U01 AG027810NIA NIH HHS U01-AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIA NIH HHS U01 AG18197
6 · The paper itself

Abstract

backgroundsmall, retrospective studies suggest that major life events and/or sudden emotional stress may increase fall and fracture risk. The current study examines these associations prospectively.

methodsa total of 5,152 men aged ≥65 years in the Osteoporotic Fractures in Men study self-reported data on stressful life events for 1 year prior to study Visit 2. Incident falls and fractures were ascertained for 1 year after Visit 2. Fractures were centrally confirmed.

resultsa total of 2,932 (56.9%) men reported ≥1 type of stressful life event. In men with complete stressful life event, fall and covariate data (n = 3,949), any stressful life event was associated with a 33% increased risk of incident fall [relative risk (RR) 1.33, 95% confidence interval (CI) 1.19-1.49] and 68% increased risk of multiple falls (RR = 1.68, 95% CI = 1.40-2.01) in the year following Visit 2 after adjustment for age, education, Parkinson's disease, diabetes, stroke, instrumental activities of daily living (IADL) impairment, chair stand time, walk speed, multiple past falls, depressive symptoms and antidepressant use. Risk increased with the number of types of stressful life events. Though any stressful life event was associated with a 58% increased age-adjusted risk for incident fracture, this association was attenuated and no longer statistically significant after additional adjustment for total hip bone mineral density, fracture after age 50, Parkinson's disease, stroke and IADL impairment.

conclusionsin this cohort of older men, stressful life events significantly increased risk of incident falls independent of other explanatory variables, but did not independently increase incident fracture risk.

Indexed as

Accidental FallsLife Change EventsAgedAge FactorsHumansIncidenceMaleOsteoporotic FracturesProspective StudiesRisk FactorsSex FactorsStress, PsychologicalTime FactorsUnited Statesaccidental fallsagedfractureslife change eventsmalemenolder peopleprospective studiespsychological stress

Identifiers

PMID24002237
PMCPMC3861336

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.