ArticleJournal of biomedical optics2013
Needle-based fluorescence endomicroscopy via structured illumination with a plastic, achromatic objective.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Hybrid endomicroscopic objective with monolithic multi-material achromatic triplet fabricated using two-photon lithography.Applied optics · 2026Article
- Novel Design and Application of High-NA Fiber Imaging Bundles for In Vivo Brain Imaging with Two-Photon Scanning Fluorescence Microscopy.ACS applied materials & interfaces · 2023Article
- Automatic motion compensation for structured illumination endomicroscopy using a flexible fiber bundle.Journal of biomedical optics · 2020Article
- In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope.Biomedical optics express · 2020Article
- Handheld line-scanned dual-axis confocal microscope with pistoned MEMS actuation for flat-field fluorescence imaging.Optics letters · 2019Article
- Line-scanning confocal microendoscope for nuclear morphometry imaging.Journal of biomedical optics · 2017Article
- Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology.Journal of biomedical optics · 2017Article
- Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Algorithms for differentiating between images of heterogeneous tissue across fluorescence microscopes.Biomedical optics express · 2016Article
- Line-scanning fiber bundle endomicroscopy with a virtual detector slit.Biomedical optics express · 2016Article
- Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer.Cancer research · 2015Article
- Micro-anatomical quantitative optical imaging: toward automated assessment of breast tissues.Breast cancer research : BCR · 2015Article
- Optimizing modulation frequency for structured illumination in a fiber-optic microendoscope to image nuclear morphometry in columnar epithelium.Biomedical optics express · 2015Article
- Performance evaluation of endoscopic Cerenkov luminescence imaging system: in vitro and pseudotumor studies.Biomedical optics express · 2014Article
- Dual-axis confocal microscopy for point-of-care pathology.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In order to diagnose cancer, a sample must be removed, prepared, and examined under a microscope, which is expensive, invasive, and time consuming. Fiber optic fluorescence endomicroscopy, where an image guide is used to obtain high-resolution images of tissue in vivo, has shown promise as an alternative to conventional biopsies. However, the resolution of standard endomicroscopy is limited by the fiber bundle sampling frequency and out-of-focus light. A system is presented which incorporates a plastic, achromatic objective to increase the sampling and which provides optical sectioning via structured illumination to reject background light. An image is relayed from the sample by a fiber bundle with the custom 2.1-mm outer diameter objective lens integrated to the distal tip. The objective is corrected for the excitation and the emission wavelengths of proflavine (452 and 515 nm). It magnifies the object onto the fiber bundle to improve the system's lateral resolution by increasing the sampling. The plastic lenses were fabricated via single-point diamond turning and assembled using a zero alignment technique. Ex vivo images of normal and neoplastic murine mammary tissues stained with proflavine are captured. The system achieves higher contrast and resolves smaller features than standard fluorescence endomicroscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.