ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Leptin signaling in the medial nucleus tractus solitarius reduces food seeking and willingness to work for food.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Nucleus of the solitary tract regulation of cue-induced appetitive behaviors via midbrain dopamine neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The hindbrain-hypothalamic noradrenergic pathway controls homeostatic food intake but not cue-induced appetitive behaviors.Journal of neuroendocrinology · 2026Article
- GIPR-Ab/GLP-1 peptide-antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice.Nature metabolism · 2025Article
- CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Hindbrain ghrelin and liver-expressed antimicrobial peptide 2, ligands for growth hormone secretagogue receptor, bidirectionally control food intake.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats.Nature communications · 2023Article
- Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms.Diabetes, obesity & metabolism · 2022Article
- NTS and VTA oxytocin reduces food motivation and food seeking.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues in male rats.Hormones and behavior · 2020Article
- Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity.American journal of physiology. Endocrinology and metabolism · 2020Article
- Central leptin signaling transmits positive valence.Brain research · 2019Article
- Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormone.Nature communications · 2019Article
- Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems.Physiology & behavior · 2018Review
- The hindbrain is a site of energy balance action for prolactin-releasing peptide: feeding and thermic effects from GPR10 stimulation of the nucleus tractus solitarius/area postrema.Psychopharmacology · 2018Article
- Hyperpalatability and the Generation of Obesity: Roles of Environment, Stress Exposure and Individual Difference.Current obesity reports · 2018Review
- Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons.Frontiers in psychiatry · 2018Review
- Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus-Ventral Tegmental Area Neurocircuitry Depends on Energy State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Physiological state tunes mesolimbic signaling: Lessons from sodium appetite and inspiration from Randall R. Sakai.Physiology & behavior · 2017Review
- Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Regional influence of cocaine on evoked dopamine release in the nucleus accumbens core: A role for the caudal brainstem.Brain research · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The adipose-derived hormone leptin signals in the medial nucleus tractus solitarius (mNTS) to suppress food intake, in part, by amplifying within-meal gastrointestinal (GI) satiation signals. Here we show that mNTS leptin receptor (LepRb) signaling also reduces appetitive and motivational aspects of feeding, and that these effects can depend on energy status. Using the lowest dose that significantly suppressed 3-h cumulative food intake, unilateral leptin (0.3 μg) administration to the mNTS (3 h before testing) reduced operant lever pressing for sucrose under increasing work demands (progressive ratio reinforcement schedule) regardless of whether animals were energy deplete (food restricted) or replete (ad libitum fed). However, in a separate test of food-motivated responding in which there was no opportunity to consume food (conditioned place preference (CPP) for an environment previously associated with a palatable food reward), mNTS leptin administration suppressed food-seeking behavior only in chronically food-restricted rats. On the other hand, mNTS LepRb signaling did not reduce CPP expression for morphine reinforcement regardless of energy status, suggesting that mNTS leptin signaling differentially influences motivated responding for food vs opioid reward. Overall results show that mNTS LepRb signaling reduces food intake and appetitive food-motivated responding independent of energy status in situations involving orosensory and postingestive contact with food, whereas food-seeking behavior independent of food consumption is only reduced by mNTS LepRb activation in a state of energy deficit. These findings reveal a novel appetitive role for LepRb signaling in the mNTS, a brain region traditionally linked with processing of meal-related GI satiation signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.