Evidence map›Paper›PMID 24001524›Full record

ArticleEpidemiology and infection2014

Temporal and spatial variation in Anaplasma phagocytophilum infection in Swedish moose (Alces alces).

J Malmsten, D Gavier Widén, G Rydevik, L Yon, M R Hutchings, C-G Thulin, L Söderquist, A Aspan, S Stuen, A-M Dalin

Open access · bronzeAbstract read
In one paragraph

Article in Epidemiology and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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  4. Prevalence and Genotyping ofAnimals : an open access journal from MDPI · 2022
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  5. Review
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  11. Review
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

J MalmstenDepartment of Pathology and Wildlife Diseases, National Veterinary Institute, Uppsala, Sweden.
D Gavier WidénDivision of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
G RydevikBiomathematics and Statistics Scotland, University of Edinburgh, Edinburgh, UK.
L YonUniversity of Nottingham School of Veterinary Medicine & Science, Sutton Bonington, UK.
M R HutchingsDisease Systems, Scottish Agricultural College, Edinburgh, UK.
C-G ThulinCentre for Fish and Wildlife Research, Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.
L SöderquistDepartment of Pathology and Wildlife Diseases, National Veterinary Institute, Uppsala, Sweden.
A AspanDepartment of Bacteriology, National Veterinary Institute, Uppsala, Sweden.
S StuenDepartment of Production Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.
A-M DalinDepartment of Pathology and Wildlife Diseases, National Veterinary Institute, Uppsala, Sweden.
Swedish University of Agricultural Sciences · SESwedish Veterinary Agency · SEBiomathematics and Statistics Scotland · GBNorwegian University of Life Sciences · NOScottish Agricultural Science Agency · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryThe occurrence of Anaplasma phagocytophilum was investigated in spleen and serum samples from Swedish moose (Alces alces) in southern Sweden (island and mainland). Samples were analysed for presence of A. phagocytophilum DNA by real-time PCR (n = 263), and for Anaplasma antibodies with ELISA serology (n = 234). All serum samples had antibodies against A. phagocytophilum. The mean DNA-based prevalence was 26·3%, and significant (P < 0·01) temporal, and spatial variation was found. Island moose had significantly (P < 0·001) higher prevalence of A. phagocytophilum DNA than moose from the mainland areas. Two samples were sequenced to determine genetic variation in the 16S rRNA and groESL genes. Genetic sequence similarity with the human granulocytic anaplasmosis agent, equine granulocytic ehrlichiosis agent, and different wildlife-associated A. phagocytophilum variants were observed in the 16S rRNA and groESL genes. Our study shows that moose are exposed to A. phagocytophilum in Sweden, and represent a potential wildlife reservoir of the pathogen.

Indexed as

DeerAnaplasma phagocytophilumAnimalsAntibodies, BacterialBacterial ProteinsChaperoninsDisease ReservoirsDNA, BacterialEhrlichiosisEnzyme-Linked Immunosorbent AssayFemaleGene Expression Regulation, BacterialGenetic VariationMaleReal-Time Polymerase Chain ReactionRNA, BacterialAntibodies, BacterialBacterial ProteinsChaperoninsDNA, BacterialGroESL protein, BacteriaRNA, BacterialRNA, Ribosomal, 16S

Identifiers

PMID24001524
PMCPMC4045167
OpenAlexW2130472345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.