ArticleBiological psychiatry2014
Genetic overlap between evoked frontocentral theta-band phase variability, reaction time variability, and attention-deficit/hyperactivity disorder symptoms in a twin study.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bridging Genetic Insights with Neuroimaging in Autism Spectrum Disorder-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Overlaps and distinctions between attention deficit/hyperactivity disorder and autism spectrum disorder in young adulthood: Systematic review and guiding framework for EEG-imaging research.Neuroscience and biobehavioral reviews · 2019Pooled it
- Theta/Beta Ratio Neurofeedback Effects on Resting and Task-Related Theta Activity in Children with ADHD.Applied psychophysiology and biofeedback · 2025Trial
- The efficacy of Ritalin in ADHD children under neurofeedback training.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Trial
- Methylphenidate ameliorates depressive comorbidity in ADHD children without any modification on differences in serum melatonin concentration between ADHD subtypes.International journal of molecular sciences · 2014Trial
- Reduced occurrence of alpha waves during resting state predicts high attention-deficit/hyperactivity disorder traits in young adults.JCPP advances · 2026Article
- Dissociable Trait Correlates of P300 Variability and Amplitude: Conscientiousness and Disinhibition.Psychophysiology · 2026Article
- ADHD polygenic risk predicts neural signatures of cognitive control: Evidence from midfrontal theta dynamics.Translational psychiatry · 2026Article
- Resting low-frequency EEG correlates of adult ADHD trait symptoms beyond internalizing symptoms in young adults.Frontiers in human neuroscience · 2026Article
- Reduced Theta Inter-Trial Phase Coherence in Error Processing: A Marker of Neural Dysfunction in Attention Deficit Hyperactivity Disorder.Psychophysiology · 2025Article
- Cardiac-Sympathetic Contractility and Neural Alpha-Band Power: Cross-Modal Collaboration during Approach-Avoidance Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Gender differences in the associations between childhood adversity and psychopathology in the general population.Social psychiatry and psychiatric epidemiology · 2024Article
- Cognitive-attentional mechanisms of cooperation-with implications for attention-deficit hyperactivity disorder and cognitive neuroscience.Cognitive, affective & behavioral neuroscience · 2023Article
- Genetic Overlap Between Midfrontal Theta Signals and Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Longitudinal Twin Cohort.Biological psychiatry · 2023Article
- A hypothesis - generating Swedish extended national cross-sectional family study of multimorbidity severity and venous thromboembolism.BMJ open · 2023Article
- Familial aggregation of multimorbidity in Sweden: national explorative family study.BMJ medicine · 2023Article
- Can biomarkers be used to diagnose attention deficit hyperactivity disorder?Frontiers in psychiatry · 2023Review
- Co-Occurrence of Tic Disorders and Attention-Deficit/Hyperactivity Disorder-Does It Reflect a Common Neurobiological Background?Biomedicines · 2022Review
- Genetic polymorphisms iniScience · 2022Article
- Quality of life, functional impairment and continuous performance task event-related potentials (ERPs) in young adults with ADHD and autism: A twin study.JCPP advances · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundElectrophysiological and hemodynamic activity is altered in attention-deficit/hyperactivity disorder (ADHD) during tasks requiring cognitive control. Frontal midline theta oscillations are a cortical correlate of cognitive control influencing behavioral outcomes including reaction times. Reaction time variability (RTV) is consistently increased in ADHD and is known to share genetic effects with the disorder. The etiological relationship between the cognitive control system, RTV, and ADHD is unknown. In a sample of twins selected for ADHD and matched control subjects, we aimed to quantify the strength of the phenotypic, genetic, and environmental relationships between event-related midline theta oscillations, RTV, and ADHD.
methodsOur sample included 134 participants aged 12 to 15 years: 67 twin pairs (34 monozygotic; 33 dizygotic) with concordance or discordance for ADHD symptomatology assessed at 8, 10, and 12 years of age. Our main outcome measures were frontal midline theta activity, derived from both channel and source decomposed electroencephalographic data, and behavioral performance on a response-choice arrow flanker task known to elicit theta activity.
resultsVariability in stimulus event-related theta phase from frontal midline cortex is strongly related to both RTV and ADHD, both phenotypically and genetically.
conclusionsThis is the first finding to confirm the genetic link between the frontal midline cognitive control system and ADHD and the first to identify a genetically related neurophysiological marker of RTV in ADHD. Variability in the timing of the theta signal in ADHD may be part of a dysfunctional brain network that impairs regulation of task-relevant responses in the disorder.
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