ArticleAntioxidants & redox signaling2014
Does dietary iodine regulate oxidative stress and adiponectin levels in human breast milk?
Article in Antioxidants & redox signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Breast Milk Iodine Concentration (BMIC) as a Biomarker of Iodine Status in Lactating Women and Children <2 Years of Age: A Systematic ReviewNutrients · 2022Pooled it
- Biofortification of Vegetables with Iodine and Molybdenum for Healthy Nutrition: A Controlled Trial.Nutrients · 2025Trial
- Antioxidant Capacity of Colostrum of Mothers with Gestational Diabetes Mellitus-A Cross-Sectional Study.Nutrients · 2025Article
- The impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes: A scoping review.PloS one · 2025Article
- The correlation between iodine and metabolism: a review.Frontiers in nutrition · 2024Review
- The Gestational Pathologies Effect on the Human Milk Redox Homeostasis: A First Step towards Its Definition.Nutrients · 2023Article
- Review
- Is breast milk iodine concentration an influential factor in growth- and obesity-related hormones and infants' growth parameters?Maternal & child nutrition · 2021Article
- Iodine Deficiency and Mortality in Spanish Adults: Di@bet.es Study.Thyroid : official journal of the American Thyroid Association · 2021Observational
- Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway.Journal of clinical medicine · 2020Article
- Review
- Growth hormone-releasing hormone is produced by adipocytes and regulates lipolysis through growth hormone receptor.International journal of obesity (2005) · 2017Article
- The pro-/anti-inflammatory effects of different fatty acids on visceral adipocytes are partially mediated by GPR120.European journal of nutrition · 2017Article
- The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Protective effect of KI in mtDNA in porcine thyroid: comparison with KIO₃ and nDNA.European journal of nutrition · 2015Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the association between iodine and human milk composition. In this study, we investigated the association between iodine and different markers of oxidative stress and obesity-related hormones in human breast milk. This work is composed of two cross-sectional studies (in lactating women and in the general population), one prospective and one in vitro. In the cross-sectional study in lactating women, the breast milk iodine correlated negatively with superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) activities, and with adiponectin levels. An in vitro culture of human adipocytes with 1 μM potassium iodide (KI, dose similar to the human breast milk iodine concentration) produced a significant decrease in adiponectin, GSH-Px, SOD1, and SOD2 mRNA expression. However, after 2 months of treatment with KI in the prospective study, a positive correlation was found between 24-h urinary iodine and serum adiponectin. Our observations lead to the hypothesis that iodine may be a factor directly involved in the regulation of oxidative stress and adiponectin levels in human breast milk.
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Registered trials
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