ArticleASN neuro2013
Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens.
Article in ASN neuro, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders.Molecular psychiatry · 2026Article
- Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seeking.Science advances · 2026Article
- Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- 3D Synaptic Organization of the Rat CA1 and Alterations Induced by Cocaine Self-Administration.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Prenatal alcohol exposure reduces posterior dorsomedial striatum excitability and motivation in a sex- and age-dependent fashion.Neuropharmacology · 2020Article
- Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex.Neurobiology of learning and memory · 2020Review
- Differential mitochondrial morphology in ventral striatal projection neuron subtypes.Journal of neuroscience research · 2019Article
- Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice.Journal of neurophysiology · 2018Article
- Contributions of prolonged contingent and non-contingent cocaine exposure to escalation of cocaine intake and glutamatergic gene expression.Psychopharmacology · 2018Article
- Regional Differences in Striatal Neuronal Ensemble Excitability Following Cocaine and Extinction Memory Retrieval in Fos-GFP Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- An animal model of differential genetic risk for methamphetamine intake.Frontiers in neuroscience · 2015Review
- HIV-1 transgenic female rat: synaptodendritic alterations of medium spiny neurons in the nucleus accumbens.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Article
- Dopamine receptor blockade modulates the rewarding and aversive properties of nicotine via dissociable neuronal activity patterns in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
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- Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3).eNeuroArticle
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
To examine the mechanisms of drug relapse, we first established a model for cocaine IVSA (intravenous self-administration) in mice, and subsequently examined electrophysiological alterations of MSNs (medium-sized spiny neurons) in the NAc (nucleus accumbens) before and after acute application of cocaine in slices. Three groups were included: master mice trained by AL (active lever) pressings followed by IV (intravenous) cocaine delivery, yoked mice that received passive IV cocaine administration initiated by paired master mice, and saline controls. MSNs recorded in the NAc shell in master mice exhibited higher membrane input resistances but lower frequencies and smaller amplitudes of sEPSCs (spontaneous excitatory postsynaptic currents) compared with neurons recorded from saline control mice, whereas cells in the NAc core had higher sEPSCs frequencies and larger amplitudes. Furthermore, sEPSCs in MSNs of the shell compartment displayed longer decay times, suggesting that both pre- and postsynaptic mechanisms were involved. After acute re-exposure to a low-dose of cocaine in vitro, an AP (action potential)-dependent, persistent increase in sEPSC frequency was observed in both NAc shell and core MSNs from master, but not yoked or saline control mice. Furthermore, re-exposure to cocaine induced membrane hyperpolarization, but concomitantly increased excitability of MSNs from master mice, as evidenced by increased membrane input resistance, decreased depolarizing current to generate APs, and a more negative Thr (threshold) for firing. These data demonstrate functional differences in NAc MSNs after chronic contingent versus non-contingent IV cocaine administration in mice, as well as synaptic adaptations of MSNs before and after acute re-exposure to cocaine. Reversing these functional alterations in NAc could represent a rational target for the treatment of some reward-related behaviors, including drug addiction.
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