ArticleBMC musculoskeletal disorders2013
An inverted J-shaped association of serum uric acid with muscle strength among Japanese adult men: a cross-sectional study.
Article in BMC musculoskeletal disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- Trial
- Inverted U-Shaped Association Between Serum Uric Acid and Handgrip Strength in Chinese Community-Dwelling Adults: A Repeated-Measures Cohort Study.Biomedicines · 2026Article
- Temporal relationship between serum uric acid and muscle strength: a cross-sectional and longitudinal study of middle-aged and older adults.Scientific reports · 2025Article
- Association of Serum Uric Acid With Relative Muscle Loss: A US Population-Based Cross-Sectional Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Recovery of Physical Function during Hospitalization among Heart Failure Patients with and without Cachexia.Physical therapy research · 2025Article
- Multimodal data-driven prognostic model for predicting long-term outcomes in older adult patients with sarcopenia: a retrospective cohort study.Frontiers in public health · 2025Article
- Impact of Glucose Profile, Fasting Insulin, and Renal Function on Sarcopenia in Elderly at Single Centered Nursing Home: A Cross-Sectional Structural Equation Model Analysis.Journal of multidisciplinary healthcare · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Article
- Diagnostic accuracy of isometric knee extension strength as a sarcopenia criteria in older women.BMC geriatrics · 2024Article
- Muscle Mass and Muscle Strength in Non-Dialysis-Dependent Chronic Kidney Disease Patients.Journal of clinical medicine · 2024Article
- Uric acid formation is driven by crosstalk between skeletal muscle and other cell types.JCI insight · 2024Article
- The correlations of serum uric acid with lean mass, fat mass and grip strength in adolescents aged 12-19 years.Frontiers in endocrinology · 2024Article
- The agreement of low lean mass with obesity using different definitions and its correlation with hyperuricemia.Frontiers in nutrition · 2024Article
- Hyperuricemia may be associated with muscle wellness in older adults.International urology and nephrology · 2023Article
- Association between elevated serum uric acid levels and high estimated glomerular filtration rate with reduced risk of low muscle strength in older people: a retrospective cohort study.BMC geriatrics · 2023Article
- Association between the 110-kDa C-terminal agrin fragment and skeletal muscle decline among community-dwelling older women.Journal of cachexia, sarcopenia and muscle · 2023Article
- Article
- Not only muscle mass but also muscle quality is associated with knee extension muscle strength in patients with hip fractures.Archives of osteoporosis · 2023Article
- Causality between urate levels with sarcopenia-related traits: a bi-directional Mendelian randomization study.Frontiers in endocrinology · 2023Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUric acid (UA) may protect muscle function from oxidative damage due to reactive oxygen species through its powerful antioxidant capacity. However, several studies have demonstrated that hyperuricemia is closely related to systemic inflammation and has oxidant properties effects, both of which may increase the risk of muscle strength loss. The purpose of this study was to examine the association of serum UA concentration with grip strength and leg extension power in adult men.
methodsThis study is a cross-sectional survey in which 630 Japanese male employees aged 30 years and older participated. Five hundred and eighty-six subjects participated in the measurement of grip strength, and 355 subjects participated in the measurement of leg extension power. Blood samples were obtained for serum UA analysis.
resultsAfter adjustment for potential confounders, grip strength differed significantly between participants with and those without hyperuricemia (geometric mean and 95% confidence interval [CI]: 40.3 [39.2-41.3] kg vs. 41.9 [41.3-42.5] kg; P = 0.01). In addition, serum UA levels (quartiles) showed an inverted J-shaped curve with grip strength (mean and 95% CI: Q1, 41.6 [40.6-42.6] kg; Q2, 42.2 [41.2-43.2] kg; Q3, 41.8 [40.8-42.8] kg; Q4, 40.4 [39.3-41.4] kg; P for quadratic trend = 0.05). The results in the leg extension power group were similar to those observed in the grip strength group.
conclusionThis population-based cross-sectional study shows for the first time that hyperuricemia is associated with poor muscle strength. Moreover, the results indicate an inverted J-shaped association between serum UA quartiles and muscle strength.
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