ArticleComputational and mathematical methods in medicine2013
Excitation-contraction coupling between human atrial myocytes with fibroblasts and stretch activated channel current: a simulation study.
Article in Computational and mathematical methods in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Progress on role of ion channels of cardiac fibroblasts in fibrosis.Frontiers in physiology · 2023Review
- Effects of fibroblast on electromechanical dynamics of human atrial tissue-insights from a 2D discrete element model.Frontiers in physiology · 2022Article
- Regional Diversities in Fibrogenesis Weighed as a Key Determinant for Atrial Arrhythmogenesis.Biomedicines · 2021Review
- Stretch-activated current in human atrial myocytes and NaBiomedical engineering online · 2019Article
- Role of Non-Myocyte Gap Junctions and Connexin Hemichannels in Cardiovascular Health and Disease: Novel Therapeutic Targets?International journal of molecular sciences · 2018Review
- Simulation of Atrial Fibrosis Using Coupled Myocyte-Fibroblast Cellular and Human Atrial Models.Computational and mathematical methods in medicine · 2017Article
- A review of the literature on cardiac electrical activity between fibroblasts and myocytes.Progress in biophysics and molecular biology · 2016Review
- Effects of NaComputational and mathematical methods in medicine · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention. Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function. This study proposed an integrated myocyte-I sac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (I sac) on cardiac electrical excitation conduction and mechanical contraction. At the cellular level, an active Fb model was coupled with a human atrial myocyte electrophysiological model (including I sac) and a mechanical model. At the tissue level, electrical excitation conduction was coupled with an elastic mechanical model, in which finite difference method (FDM) was used to solve the electrical excitation equations, while finite element method (FEM) was used for the mechanics equations. The simulation results showed that Fbs and I sac coupling caused diverse effects on action potential morphology during repolarization, depolarized the resting membrane potential of the human atrial myocyte, slowed down wave propagation, and decreased strains in fibrotic tissue. This preliminary simulation study indicates that Fbs and I sac have important implications for modulating cardiac electromechanical behavior and should be considered in future cardiac modeling studies.
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