ArticleMetabolic brain disease2013
Aerobic fitness and cognitive function in midlife: an association mediated by plasma insulin.
Article in Metabolic brain disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: Results from the IGNITE study.Brain, behavior, & immunity - health · 2026Article
- Effects of aerobic exercise training on cerebral pulsatile hemodynamics in middle-aged adults with elevated blood pressure/stage 1 hypertension.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Insulin Homeostasis Mediates the Relationship Between Cardiorespiratory Fitness and Cognitive Speed in Aging Adults.Journal of Alzheimer's disease : JAD · 2023Observational
- Influence of sex and presence of cardiovascular risk factors on relations between cardiorespiratory fitness and cerebrovascular hemodynamics.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Cognition, Brain Structure, and Brain Function in Individuals with Obesity and Related Disorders.Current obesity reports · 2020Review
- Surgical and Nonsurgical Interventions for Obesity in Service of Preserving Cognitive Function.Psychosomatic medicineArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Insulin resistance in midlife increases the risk of dementia in late-life. In contrast, habitual aerobic exercise is an established strategy to ameliorate insulin resistance which may translate into better cognitive outcome. To determine the role of plasma insulin in mediating the relation between cardiorespiratory fitness and cognitive function, fifty-eight adults completed assessments of plasma insulin levels, maximal oxygen consumption (VO2max), and neuropsychological test performance. Endurance-trained subjects demonstrated better cognitive outcome (total composite z-score: 0.21 ± 0.08 versus -0.26 ± 0.10, P = 0.001) and lower concentrations of plasma insulin (12.6 ± 0.6 versus 21.3 ± 1.5 ulU/mL, P < 0.001) than sedentary subjects. Greater VO2max was significantly associated with higher memory performance (β = 0.37, P = 0.01) and lower plasma insulin levels (β = -0.68, P < 0.001). The significant association between VO2max and memory performance was abolished when the indirect effect of plasma insulin was statistically removed (β = 0.24, P = 0.19). Fitness-related cognitive enhancement may be mediated, at least in part, by plasma insulin levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.