Evidence map›Paper›PMID 24000053›Full record

Trial reportAIDS and behavior2014

Increasing quality of life and reducing HIV burden: the PATH+ intervention.

Michael B Blank, Michael Hennessy, Marlene M Eisenberg

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Nurse led home-based care for people with HIV/AIDS.BMC health services research · 2018
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael B BlankCenter for Mental Health Policy and Services Research, University of Pennsylvania, 3535 Market St., Philadelphia, PA, 19104-3309, USA, mblank2@mail.med.upenn.edu.
Michael Hennessy
Marlene M Eisenberg
University of Pennsylvania · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Knashawn Hodge Morales · 2013 to 2026
$23.5M
ZDV VS ZDV + DDL VS ZDV + DDL + NVP IN ASYMPTOMATIC HIV PATIENTSM01RR000040 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 1985 to 2006
$21.1M
HIV Prevention Program among Substance Abusing SMIR01DA015627 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLANK, MICHAEL B · 2003 to 2007
$3.2M
Nursing Intervention for HIV Regimen Adherence among SMIR01NR008851 · NINR · UNIVERSITY OF PENNSYLVANIA · PI BLANK, MICHAEL B · 2003 to 2007
$3.0M
NCRR NIH HHS M01 RR000040NIAID NIH HHS P30 AI045008NIAID NIH HHS P30AI045008NIDA NIH HHS R01 DA015627NIDA NIH HHS R01-DA-015627NIMH NIH HHS P30 MH097488NIMH NIH HHS P30MH097488NINR NIH HHS R01 NR008851NINR NIH HHS R01-NR-008851
6 · The paper itself

Abstract

The heightened risk of persons with serious mental illness (SMI) to contract and transmit human immunodeficiency virus (HIV) is a public health problem. Our objective was test the effectiveness of a community-based advanced practice nurse intervention to promote adherence to HIV and psychiatric treatment regimens call Preventing AIDS Through Health for Positives (PATH+). We enrolled 238 HIV-positive subjects with SMI who were in treatment at community HIV provider agencies from 2004 to 2009. Participants in the intervention group were assigned an advanced practice nurse who provided community-based care management at a minimum of one visit/week and coordinated their medical and mental healthcare for 12 months. A parallel process latent growth curve model using three data points for biomarkers (baseline, 12 and 24 months) and five data points for health related quality of life (baseline, 3, 6, 12, and 24 months) showed moderate to excellent fit for modeling changes in CD4, viral load, and mental and physical SF-12 subscales. Results suggest that positive effects for PATH+ persisted at 24 months; 12 months after the intervention ended. This project demonstrates the effectiveness of a nurse-led, community-based, individually tailored adherence intervention. We demonstrated improved outcomes in individuals with HIV/SMI and regarding health-related quality of life and reductions in disease burden.

Indexed as

Community Health ServicesDrug MonitoringQuality of LifeAdolescentAdultAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCooperative BehaviorCost-Benefit AnalysisCost of IllnessFemaleHIV InfectionsHome Care ServicesHumansLongitudinal StudiesMale

Identifiers

PMID24000053
PMCPMC3940688
OpenAlexW2023183927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.