ArticleMolecular and cellular biochemistry2013
MicroRNA-124 reduces caveolar density by targeting caveolin-1 in porcine kidney epithelial PK15 cells.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- A Review of miRNA Regulation in Japanese Encephalitis (JEV) Virus Infection.Current pharmaceutical biotechnology · 2024Review
- miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases.Cellular and molecular neurobiology · 2022Review
- Concentration of Serum Biomarkers of Brain Injury in Neonates With a Low Cord pH With or Without Mild Hypoxic-Ischemic Encephalopathy.Frontiers in neurology · 2022Article
- Caveolin-1 and MLRs: A potential target for neuronal growth and neuroplasticity after ischemic stroke.International journal of medical sciences · 2019Review
- MicroRNA-124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer.Experimental and therapeutic medicine · 2018Article
- MiR-124-3p attenuates hyperphosphorylation of Tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells.Oncotarget · 2017Article
- Transiently expressed pattern during myogenesis and candidate miRNAs of Tmem8C in goose.Journal of genetics · 2017Article
- Epigenetic Regulation of Caveolin-1 Gene Expression in Lung Fibroblasts.American journal of respiratory cell and molecular biology · 2017Article
- Review
- miR-124 attenuates Japanese encephalitis virus replication by targeting DNM2.Virology journal · 2016Article
- The miR-199-dynamin regulatory axis controls receptor-mediated endocytosis.Journal of cell science · 2015Article
- Review
- Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth.Oncotarget · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caveolin-1 is the principal component of caveolae, and it is implicated in endocytosis, cholesterol homeostasis, signal transduction and tumorigenesis. MicroRNAs play key regulatory roles in many cellular processes. However, the molecular mechanism by which porcine caveolin-1 is regulated by microRNAs remains unclear. In the present study, we found that miR-124 could directly target caveolin-1 in porcine kidney epithelial cells (PK15). A luciferase reporter assay revealed that miR-124 directly bound to Cav1 mRNA. Ectopic expression of miR-124 decreased porcine Cav1 expression at both the mRNA and protein levels. Furthermore, we used transmission electron microscopy to count caveolae in the cytosolic space next to the membrane and we found that the overexpression of miR-124 in PK15 cells reduced the density of the caveolae. Our results suggested that miR-124 reduced caveolar density by targeting caveolin-1 in PK15 cells; therefore, miR-124 could play an important role in the caveolae-mediated endocytosis of pathogens and signal transduction.
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Registered trials
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