Evidence map›Paper›PMID 23999871›Full record

ReviewMolecular neurobiology2014

Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics.

Anuradha Kalani, Alka Tyagi, Neetu Tyagi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Consequences of Aging on Bone.Aging and disease · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. GABA-Induced Exosomes Improve Memory Impairment in Aged Mice.International journal of molecular sciences · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Role of Seminal Exosomes in Reproduction.Journal of cellular physiology · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Exosome: an overview on enhanced biogenesis by small molecules.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anuradha KalaniDepartment of Physiology and Biophysics, School of Medicine, Health Sciences Center, A-1201, University of Louisville, 500 South Preston Street, Louisville, KY, 40202, USA.
Alka Tyagi
Neetu Tyagi

Funding

Mechanisms of Mitochondrial Dysfunction in Brain VasculatureR01HL107640 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU · 2012 to 2016
$1.8M
NHLBI NIH HHS HL-107640NHLBI NIH HHS R01 HL107640
6 · The paper itself

Abstract

Exosomes have emerged as prominent mediators of neurodegenerative diseases where they have been shown to carry disease particles such as beta amyloid and prions from their cells of origin to other cells. Their simple structure and ability to cross the blood-brain barrier allow great opportunity to design a "makeup" with drugs and genetic elements, such as siRNA or miRNA, and use them as delivery vehicles for neurotherapeutics. Their role in neuroprotection is evident by the fact that they are involved in the regeneration of peripheral nerves and repair of neuronal injuries. This review is focused on the role of exosomes in mediating neurodegeneration and neuroprotection.

Indexed as

AnimalsBiological TransportDrug Delivery SystemsExosomesGenetic TherapyHumansMicroRNAsNeurodegenerative DiseasesNeuroprotective AgentsRNA, Small InterferingMicroRNAsNeuroprotective AgentsRNA, Small Interfering

Identifiers

PMID23999871
PMCPMC3951279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.